Mechanobiolgocial role of endosteum and periosteum in bone remodelling

Summary

We earlier demonstrated by finite element analusis(FEA), that soft tissue dental ollicle surrounding nerupted teeth experiences compression over crowns, and tension beneath roots during normal functional loading of the jaw, with the efect that bone remodeling would be expected to lift teeth into the oclcusion. This study and others indicate a key role for soft tissues at the bone-soft tissue interface, as sensors and efectors for functional strain. Notably, bone an only remodel by either apposition of new bone matrix at th bone-sfot tissue interaface, or resorption by osteoclasts also at this critical interface, so that mechanical events at the bone soft tssue interface seem important to account for bone remodeling in respons to functional forces. Of importance for this work, is that we establsihed a method for calculation of "Biological Response Units" (BRU) in soft tissues adjacent to bone in tooth eruption, we now hypothesise that the endostium and periosteum similarly sense unctional forces in bone, and that these soft tissues play a key role in subsequent bone remodeling, accounting for the remarkable patterning of cancellous bone struts and bone surface features, in alignment with functional forces

Supervisor(s)

Dr Babak Sarrafpour

Research Location

Sydney Dental School

Program Type

PHD

Synopsis

To construct an FEA model of the sheep head of femur by micro-computerised tomography (mCT), including periostium, endosteum, cartilage and bone marrow, and in which forces applied result in minimal BRu change across cencellous bone struts and surface bone.
To geatly thin and thicken a series of bone struts and or sruface features in the EA model, and determine if BRu in adjacent endosteum and periosteum are accordingly changed following application of force compared with the unmodified FEA model.

Additional Information

Bone remodeling plays a critical role in orthodontic tooth movement as well as in the management of orthodontic skeletal defects. Similarly, bone remodeling is important in development of bony defects in periodontitis, as well as in the development of chronic periapical periodontitis, radicular cysts and all other bone occpying lesions of the jaws.

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Keywords

Bone remodeling, cancellous bone, mechanobiology, finite element analysis, endosteum, periosteum

Opportunity ID

The opportunity ID for this research opportunity is: 2397

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