Exploring the neurobiology of Parkinson’s disease with multimodal techniques


This study will examine the neurobiology underlying some of the most troubling features of Parkinson's disease. This opportunity will utilise a range of novel neuroimaging, neurophysiological and biomedical techniques to explore these clinical features, which will in turn lead to advances in the field of neurodegenerative disease and hopefully translation into improved clinical practice.


Associate Professor Simon Lewis, Associate Professor Sharon Naismith

Research Location

Camperdown - Brain and Mind Centre

Program Type



Parkinson's disease (PD) affects 1 in 1000 people and has significant personal and societal impacts. It is a progressive neurodegenerative disease with no cure and a wide range of symptoms including problems with walking, mood, sleep, hallucinations and dementia that are only partially improved by treatment. Little is known about the brain mechanisms underlying these symptoms and as such targeted treatment is limited. Recent advances in neuroimaging, neurophysiology and biomedical techniques led by our research group have given some novel insights in to our understanding of these symptoms that we now wish to translate into improved medical practice.The proposed research would utilise a broad range of objective measures to investigate the neurobiology in Parkinson's disease using techniques including Functional and Structural MRI, eye tracking and electroencephalography. The successful candidate will be responsible for developing and testing novel methods for investigating the pathophysiology associated with these symptoms. There will be a focus on the creation of novel biomarkers that can be used to monitor treatment efficacy, predict transition and ultimately, identify the emergence symptoms earlier in the course of the disease. The successful applicant will be working in a multidisciplinary research environment with a team of Neurologists, Neuropsychologists and Neuroscientists as well as other academic staff and students within the field of ageing.

Additional Information

We anticipate that the successful candidate will have completed an undergraduate degree and will have experience/interest in neuropsychology, psychology, clinical neuroscience or applied physiology. They must be eligible to apply for MPhil/PhD programs. Previous clinical research experience is desirable. A stipend may be available depending on circumstances.

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Parkinson’s Disease, heterogeneity, phenotype, functional magnetic resonance imaging (fMRI), neuroimaging, cognition, neurodegenerative disease, neuropsychology, Neuroscience, Actigraphy, electoencephalography (EEG), eye tracking.

Opportunity ID

The opportunity ID for this research opportunity is: 246