Maternal autoimmunity increases risk of neurodevelopmental problems in offspring.
Summary
Maternal autoimmunity is a recognised risk factor for autism and other neurodevelopmental and psychiatric disorders in the offspring. It is well established in humans and animal models that a proinflammatory maternal environment whilst pregnant can affect fetal brain development. This PhD will link clinical studies in humans with an animal model of maternal autoimmunity to determine the effects of inflammation during pregnancy on fetal astrocytes and microglia using molecular, cellular and microscopic techniques.
Supervisor(s)
Professor Russell Dale, Dr Markus Hofer
Research Location
Westmead - Childrens Hospital at Westmead Clinical School
Program Type
PHD
Synopsis
When pregnant, activation of the maternal immune system can negatively affect the fetal brain resulting in increased risk of neurodevelopmental and mental health problems in the offspring. This PhD project will link clinical observations (Professor Russell Dale, Paediatric Neurology, Children's Hospital Westmead) with a basic science animal model (Dr Markus Hofer, Biochemistry and Molecular Biology Cluster, School of Life and Environmental Sciences). The animal model will reproduce maternal autoimmunity and examine the effects of the activated immune environment on brain microglia in the offspring. Opportunities to modify the microglia activation in the animal model can be translated to observations in children with neurodevelopmental and mental health disease.
Additional Information
<html />
Want to find out more?
Contact us to find out what’s involved in applying for a PhD. Domestic students and International students
Contact Research Expert to find out more about participating in this opportunity.
Browse for other opportunities within the Westmead - Childrens Hospital at Westmead Clinical School .
Keywords
Maternal immune activation, autoimmunity, neurodevelopment, Psychiatry, autism
Opportunity ID
The opportunity ID for this research opportunity is: 2472
Other opportunities with Professor Russell Dale
- The role of autoantibodies against neuronal receptors in immune-mediated neurological and psychiatric disorders.
- Utility of Cerebrospinal fluid proteomics to define molecular mechanisms in brain disease of childhood.
- Epilepsy in CP advert
- Neuroscience/Neuroimmunology Research: Role of antibody in brain immune-mediated diseases
- Defining the clinical and immunogenetic profile in antibody-associated demyelination
Other opportunities with Dr Markus Hofer
- TARGETING THE BRAIN VASCULATURE AS A TREATMENT FOR CEREBRAL TYPE I INTERFERONOPATHIES
- THE PATHOGENIC AND PROTECTIVE EFFECTS OF MICROGLIA IN CEREBRAL CYTOKINOPATHIES
- HOW DIFFERENT CELL TYPES OF THE BRAIN CONTRIBUTE TO CEREBRAL CYTOKINOPATHIES
- EFFECTS OF TYPE I INTERFERONS IN CHRONIC VIRAL INFECTIONS
- Cumulative modeling of Maternal Immune Activation to assess risk factors of common neurodevelopmental disease