Interplay between Innate and adaptive immunity in kidney ischemia reperfusion injury and allograft rejection

Summary

This study is to investigate the link between innate and adaptive immunity in kidney ischemia reperfusion injury and allograft rejection with a view to identifying new therapeutic targets.

Supervisor(s)

Professor Steve Chadban, Associate Professor Huiling Wu

Research Location

Camperdown - School of Medical Sciences - Bosch Institute

Program Type

Masters/PHD

Synopsis

Allograft rejection is the major cause of premature kidney transplant failure after transplantation. Allograft rejection occurs because of an adaptive alloimmune response mediated by antigen specific T cells. Our previous results suggest that innate immune mechanisms dependent on macrophages and Toll like receptors play important roles in kidney ischemia reperfusion injury and transplantation. The aim of this study is to examine the link between innate and adaptive immunity in ischemia reperfusion injury, acute and chronic kidney rejection with a view to identifying new therapeutic targets in our animal models of kidney ischemia reperfusion injury and allograft rejection. In particular, projects focus on:

  1. The interface between innate and adaptive immunity in kidney ischemia reperfusion and allograft rejection with focus on macrophages & dendritic cells, Toll-like receptors and the interactions between immune cells and kidney cells.
  2. Targeting innate immunity to prevent ischemia reperfusion injury and kidney allograft rejection. The projects are supported by grants from the National Health and Medical Research Council and Kidney Health Australia.

Additional Information

Investigation may include in vivo and in vitro studies in animal models of kidney ischemia reperfusion injury, acute and chronic rejection. The techniques to be used include immunohistochemistry, molecular biology (RNA isolation, cDNA synthesis, real time PCR), flow cytometry (FACS), ELISA analysis and cell culture.

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Keywords

End-stage renal failure, Innate and adaptive immunity, Kidney, Ischemia reperfusion injury, Allograft rejection, macrophages, Dendritic cells, T cells, transplantation, Organ replacement, Infection & immunity

Opportunity ID

The opportunity ID for this research opportunity is: 248