Regulation of Lipid Turnover in the body

Summary

The project involves characterisation of a novel lipolysis regulator in adipocytes.

Supervisor(s)

Professor David James

Research Location

School of Life and Environmental Sciences

Program Type

PHD

Synopsis

One of the most important actions of insulin in mammals is to suppress lipolysis or fatty acid release in adipocytes. Indeed, an impairment in this process may play a major role in diseases including non-alcoholic fatty liver disease and steatohepatitis. We have recently discovered a novel regulator of lipolysis in fat cells. This project will explore how insulin regulates the function of this protein to coordinate the release of fatty acids from the lipid droplet.

Additional Information

The project will be based at the Charles Perkins Centre. The project will be supported by a range of multidisciplinary scientists and so there is a rich opportunity for training in this exciting area.


HDR Inherent Requirements
In addition to the academic requirements set out in the Science Postgraduate Handbook, you may be required to satisfy a number of inherent requirements to complete this degree. Example of inherent requirement may include:

- Confidential disclosure and registration of a disability that may hinder your performance in your degree;
- Confidential disclosure of a pre-existing or current medical condition that may hinder your performance in your degree (e.g. heart disease, pace-maker, significant immune suppression, diabetes, vertigo, etc.);
- Ability to perform independently and/or with minimal supervision;
- Ability to undertake certain physical tasks (e.g. heavy lifting);
- Ability to undertake observatory, sensory and communication tasks;
- Ability to spend time at remote sites (e.g. One Tree Island, Narrabri and Camden);
- Ability to work in confined spaces or at heights;
- Ability to operate heavy machinery (e.g. farming equipment);
- Hold or acquire an Australian driver’s licence;
- Hold a current scuba diving license;
- Hold a current Working with Children Check;
- Meet initial and ongoing immunisation requirements (e.g. Q-Fever, Vaccinia virus, Hepatitis, etc.)

You must consult with your nominated supervisor regarding any identified inherent requirements before completing your application.

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Keywords

lipid metabolism, insulin action, adipocytes, lipolysis

Opportunity ID

The opportunity ID for this research opportunity is: 2527

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