The role of redox in signalling: assessing the requirement of reactive oxygen species in signal transduction

Summary

Define the role of ROS in insulin signal transduction and explore how loss of control of this process causes diseases such as diabetes and cancer

Supervisor(s)

Professor David James

Research Location

School of Life and Environmental Sciences

Program Type

PHD

Synopsis

Reactive oxygen species (ROS) are known to be involved in the development of a multitude of diseases and are considered “bad”. However they are now becoming increasingly recognised as major players in normal signal transduction pathways and are thought to have been one of the first forms of reversible post-translational modifications, predating phosphorylation from an evolutionary perspective. Despite this little is known about their role in normal signal transduction. This project will utilise cutting edge molecular imaging techniques to define the role of ROS in signal transduction under both ‘normal’ and ‘pathological’ conditions.

Additional Information

The project will be based at the Charles Perkins Centre. The project will be supported by a range of multidisciplinary scientists and so there is a rich opportunity for training in this exciting area.
HDR Inherent Requirements

In addition to the academic requirements set out in the Science Postgraduate Handbook, you may be required to satisfy a number of inherent requirements to complete this degree. Example of inherent requirement may include:

- Confidential disclosure and registration of a disability that may hinder your performance in your degree;
- Confidential disclosure of a pre-existing or current medical condition that may hinder your performance in your degree (e.g. heart disease, pace-maker, significant immune suppression, diabetes, vertigo, etc.);
- Ability to perform independently and/or with minimal supervision;
- Ability to undertake certain physical tasks (e.g. heavy lifting);
- Ability to undertake observatory, sensory and communication tasks;
- Ability to spend time at remote sites (e.g. One Tree Island, Narrabri and Camden);
- Ability to work in confined spaces or at heights;
- Ability to operate heavy machinery (e.g. farming equipment);
- Hold or acquire an Australian driver’s licence;
- Hold a current scuba diving license;
- Hold a current Working with Children Check;
- Meet initial and ongoing immunisation requirements (e.g. Q-Fever, Vaccinia virus, Hepatitis, etc.)

You must consult with your nominated supervisor regarding any identified inherent requirements before completing your application.

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Keywords

ROS, microfluids, microscopy, single cells, Imaging, image analysis, Signalling, kinases

Opportunity ID

The opportunity ID for this research opportunity is: 2528

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