Gene editing of human stem cells and to better understand chronic pain disease

Summary

This project involves the use of human stem cells to generate pain sensing neurons and CRISPR gene editing to identify new pain killers. 
A complimentary scholarship for this project is available. To find out more, refer to the Postgraduate Research Stipend and Supplementary Scholarships in Human Genome Editing and contact A/Prof Greg Neely directly.

Supervisor(s)

Associate Professor Greg Neely

Research Location

Charles Perkins Centre - Greg Neely Lab

Program Type

PHD

Synopsis

This project will involve using human stem cells to generate and study pain sensing neurons. The successful candidate will be trained in how to handle stem cells, how to differentiate stem cells into neurons and brain organoids, CRISPR genome editing, Ca2+ imaging or electrophysiology, next generation / single cell sequencing, and mouse behavioural assays. Over the course of the study, there is also opportunities for the successful applicant to travel and receive further training in pain genomics at Harvard or Oxford through a collaborative network.

Additional Information

Exceptional applicants may qualify for an additional elite top-up scholarship worth up to $10,000 per year. To find out more, refer to the Postgraduate Research Stipend and Supplementary Scholarships in Human Genome Editing and contact A/Prof Greg Neely directly.
HDR Inherent Requirements In addition to the academic requirements set out in the Science Postgraduate Handbook, you may be required to satisfy a number of inherent requirements to complete this degree. Examples of inherent requirements may include: 

  • Confidential disclosure and registration of a disability that may hinder your performance in your degree;
  • Confidential disclosure of a pre-existing or current medical condition that may hinder your performance in your degree (e.g. heart disease, pace-maker, significant immune suppression, diabetes, vertigo, etc.);
  • Ability to perform independently and/or with minimal supervision;
  • Ability to undertake certain physical tasks (e.g. heavy lifting);
  • Ability to undertake observatory, sensory and communication tasks;
  • Ability to spend time at remote sites (e.g. One Tree Island, Narrabri and Camden);
  • Ability to work in confined spaces or at heights; Ability to operate heavy machinery (e.g. farming equipment);
  • Hold or acquire an Australian driver’s licence;
  • Hold a current scuba diving license;
  • Hold a current Working with Children Check;
  • Meet initial and ongoing immunisation requirements (e.g. Q-Fever, Vaccinia virus, Hepatitis, etc.) 
You must consult with your nominated supervisor regarding any identified inherent requirements before completing your application.

Want to find out more?

Contact us to find out what’s involved in applying for a PhD. Domestic students and International students

Contact Research Expert to find out more about participating in this opportunity.

Browse for other opportunities within the Charles Perkins Centre - Greg Neely Lab .

Keywords

Stem cells, CRISPR, Genome editing, Neuroscience, functional genomics, DNA

Opportunity ID

The opportunity ID for this research opportunity is: 2633

Other opportunities with Associate Professor Greg Neely