Gene editing of stem cells or cancer to develop new stem cell therapies to treat human disease

Summary

This project involves the use of human stem cells and CRISPR genome editing to study basic signalling pathways controlling stem cell differentiation and/or cancer. 
A complimentary scholarship for this project is available. To find out more, refer to the Postgraduate Research Stipend and Supplementary Scholarships in Human Genome Editing and contact A/Prof Greg Neely directly.

Supervisor(s)

Associate Professor Greg Neely

Research Location

Charles Perkins Centre - Greg Neely Lab

Program Type

PHD

Synopsis

This project will involve using human stem cells or patient derived cancer cell lines to investigate basic signalling mechanisms controlling pluripotency. The successful candidate will be trained in how to handle stem cells or patient derived cell lines, how to differentiate stem cells into various tissues, CRISPR genome editing, next generation / single cell sequencing, and mouse genetic or cancer models as appropriate. Over the course of the study, there is also opportunities for the successful applicant to travel and receive further training stem cell or cancer biology in the USA or Europe through a collaborative network.

Additional Information

Exceptional applicants may qualify for an additional elite top-up scholarship worth up to $10,000 per year. To find out more, refer to the Postgraduate Research Stipend and Supplementary Scholarships in Human Genome Editing and contact A/Prof Greg Neely directly. 
HDR Inherent RequirementsIn addition to the academic requirements set out in the Science Postgraduate Handbook, you may be required to satisfy a number of inherent requirements to complete this degree. Examples of inherent requirements may include: 

  • Confidential disclosure and registration of a disability that may hinder your performance in your degree;
  • Confidential disclosure of a pre-existing or current medical condition that may hinder your performance in your degree (e.g. heart disease, pace-maker, significant immune suppression, diabetes, vertigo, etc.);
  • Ability to perform independently and/or with minimal supervision; Ability to undertake certain physical tasks (e.g. heavy lifting);
  • Ability to undertake observatory, sensory and communication tasks;
  • Ability to spend time at remote sites (e.g. One Tree Island, Narrabri and Camden);
  • Ability to work in confined spaces or at heights;
  • Ability to operate heavy machinery (e.g. farming equipment);
  • Hold or acquire an Australian driver’s licence;
  • Hold a current scuba diving license;
  • Hold a current Working with Children Check;
  • Meet initial and ongoing immunisation requirements (e.g. Q-Fever, Vaccinia virus, Hepatitis, etc.)
You must consult with your nominated supervisor regarding any identified inherent requirements before completing your application.

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Keywords

Stem cells, CRISPR, Genome editing, functional genomics, Cancer

Opportunity ID

The opportunity ID for this research opportunity is: 2634

Other opportunities with Associate Professor Greg Neely