Examining the role of ABC transporter proteins in the development of Alzheimer’s disease

Summary

Cholesterol and other lipids have been shown to be related to the development of chronic disease including Alzheimer's disease. This project will study aspects of the cellular processes that regulate the activity of several ATP-binding cassette transporters, or ABC transporters, that transport lipids and other substrates out of cells. These transporters have been shown to be extensively regulated at the post-translational level, including phosphorylation and ubiquitination. Our lab has identified a number of E3-ubiquitin ligases that are important in the regulation of these transporters. We are currently building on this knowledge to further study these cellular processes in more detail.

Supervisor(s)

Dr Ingrid Gelissen

Research Location

Sydney Pharmacy School

Program Type

Masters/PHD

Synopsis

  

Additional Information

Additional Supervisor(s): A/Prof Richard Callaghan, ANU Canberra

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Keywords

Alzheimer’s disease; cholesterol; lipids; cell biology; oxysterols; post-translational processes; neurons; blood brain barrier endothelium

Opportunity ID

The opportunity ID for this research opportunity is: 2701