Identifying the principles of cell growth and cell mass regulation. Development of biomedical applications based on real-time cell mass detection.

Summary

Identifying the principles of cell growth and cell mass regulation. Development of applications based on real-time cell mass detection. Development of instrumentation, sensors and microscopies for biomedical applications.

Supervisor(s)

Dr David Martinez Martin

Research Location

Biomedical Engineering - BMIT, School of Physics, Brain and Mind Centre

Program Type

PHD

Synopsis

Cell growth and mass regulation is a fundamental process for all living organisms, yet it is poorly understood – partly due to our inability to detect changes in mass at cellular level. We develop technologies that measure and monitor cell growth in real time at the single-cell level, enhancing our understanding of cell development. Considering that dysregulation of cell mass is a critical underlying force in the development and progression of many diseases, understanding how cells regulate their mass has enormous potential to transform the way we diagnose, monitor and treat disease conditions such as cancer, diabetes, obesity, cardiovascular disease, ageing or infectious diseases. Our research is at the interphase of engineering, biology and physics, and involves working with exciting methods and techniques of microfabrication, nanotechnology, advanced optical microscopies, programming, cell biology, atomic force microscopy,etc.

Additional Information

We are stablishing a new lab in The University of Sydney. We develop and apply new technologies to discover how cells really work and function. One of our main interests is to understand how cells regulate their own mass and growth, which has an enormous potential to transform the way we treat and diagnose disorders such as cancer, diabetes, obesity, ageing, infectious diseases, cardiovascular disease, etc. We have invented a cell picobalance (also known as Cytomass Monitor) that enable us to track cellular mass changes in real time at the single cell level while monitoring their activity optically.

We are looking for PhD students and Postdocs with interest in having an impact in research at the interphase of engineering, biology, physics and nanotechnology. Highly motivated individuals who have at least several of the skills listed below are invited to apply:

GPA above 8 out 10 or equivalent
Experience with atomic force microscopy and/or related techniques
Experience with live cell imaging (optical microscopies)
Experience with cell culture and cell biology
Experience with LabView programming and automation
Experience with Python programming
Experience with AI algorithms for data analysis
Good hands-on experience with instrument operation and sample preparation
Good interpersonal skills
Can-do approach attitude

Selected candidates will be supported to apply for adequate scholarships and/or fellowships. The positions will be subject to successful funding applications.

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Keywords

cell growth, cell mass, intracellular water, cell size, cell death, Apoptosis, necrosis, Diagnostics, nanotechnology, mechanobiology, bionanotechnology, Biophysics, cellular biophysics, biomedical engineering, picobalance, cytomass monitor, biosensors, Atomic force microscopy, technology development, instrumentation, identification of the principles that govern cell mass regulation. Cell mass regulation in health and disease. Development of biomedical applications based on real-time cell mass detection.

Opportunity ID

The opportunity ID for this research opportunity is: 2789