CHARACTERISATION OF ERUSIOLIN - A NEW PEPTIDE HORMONE

Summary

In this project we aim to characterise the function of a new gut-derived peptide we have discovered in human plasma, named erusiolin, which we hypothesise plays a role in appetite regulation. With the global pandemic of obesity and its associated burden of metabolic disease, advances in our understanding of appetite regulation are critical to develop new effective therapies. Using a novel analytical approach, we have discovered and started characterisation of a new putative hormone called erusiolin. We hypothesise that erusiolin is a new hormone that acts in parallel with ghrelin to trigger food intake.

Supervisor(s)

Dr Mark Larance

Research Location

School of Life and Environmental Sciences

Program Type

PHD

Synopsis

In this project, we will examine the role of erusiolin in controlling food intake in both healthy and diseased states using human samples and mouse models, which will allow us to detail the molecular mechanisms linking its secretion from the gut to appetite stimulation. These studies will enhance our understanding of appetite regulation and could lead to the development of novel therapeutic approaches aimed at reducing food intake in patients with obesity. The specific aims of this project are:

  1. Determine the effects of erusiolin perturbation (either loss, or gain) on animal behaviour including appetite and metabolism.
  2. Identify the erusiolin receptor to provide insight into the hormone's mechanism of action.
  3. Characterise the nutrient-dependent release of erusiolin into the blood of healthy and obese patients.

Additional Information

HDR Inherent Requirements

In addition to the academic requirements set out in the Science Postgraduate Handbook, you may be required to satisfy a number of inherent requirements to complete this degree. Example of inherent requirement may include:

- Confidential disclosure and registration of a disability that may hinder your performance in your degree;
- Confidential disclosure of a pre-existing or current medical condition that may hinder your performance in your degree (e.g. heart disease, pace-maker, significant immune suppression, diabetes, vertigo, etc.);
- Ability to perform independently and/or with minimal supervision;
- Ability to undertake certain physical tasks (e.g. heavy lifting);
- Ability to undertake observatory, sensory and communication tasks;
- Ability to spend time at remote sites (e.g. One Tree Island, Narrabri and Camden);
- Ability to work in confined spaces or at heights;
- Ability to operate heavy machinery (e.g. farming equipment);
- Hold or acquire an Australian driver’s licence;
- Hold a current scuba diving license;
- Hold a current Working with Children Check;
- Meet initial and ongoing immunisation requirements (e.g. Q-Fever, Vaccinia virus, Hepatitis, etc.)

You must consult with your nominated supervisor regarding any identified inherent requirements before completing your application.

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Keywords

Peptide; hormone; blood; plasma; endocrinology; mass spectrometry; proteomics; knock-out mouse; clinical trial

Opportunity ID

The opportunity ID for this research opportunity is: 2832

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