Clinical outcomes analysis of patients who undergo resection of neuroendocrine liver metastases

Summary

The Upper GI surgery department at RNSH is a tertiary referral unit which has treated many patients with neuroendocrine tumours over the past 20 years. RNSH is recognized as a NSW centre of excellence in the treatment of patients with neuroendocrine tumours. The Hepato-Biliary surgeons have a special interest in the management of patients with neuroendocrine liver metastases. There is a large prospective clinical database which contains many patients with this condition. The Project will involve collating outcomes data from an international surgical unit with a large experience with this condition with data from RNSH for the purpose to preparing a manuscript for publication. This work could form part of a Masters of Surgery or SMP MD project. If interested the candidate could enroll in a PhD and work in conjunction with the Nuclear Medicine Department at RNSH. This group has a major clinical and research interest in neuroendocrine tumours and they have collected an extensive database of clinical material for analysis

Supervisor(s)

Professor Thomas J Hugh

Research Location

Royal North Shore Hospital (RNSH)

Program Type

Masters/PHD

Synopsis

Presentation and management of patients with neuroendocrine liver metastases
The HPB Unit at RNSH has treated many patients with neuroendocrine tumours and has a special interest in the management of patients with neuroendocrine liver metastases. The large prospective clinical database contains many patients with this condition and will involve examining the presenting features and investigation and treatment of these patients.

Clinical and molecular markers of early tumour recurrence in patients with malignant hepato-biliary tumours
Clinical and molecular markers of metastatic potential in colorectal cancer, Stromal biomarker patterns in colorectal liver metastases These projects will be done in conjunction with Professor Mark Molloy in the Colorectal Cancer Genetics laboratory in the Kolling Institute at RNSH. Using frozen tumour tissue and sera collected and stored in the Upper GI tumour biobank, a range of biomarkers will be analysed using proteomic and genomic tools to help understand the risk of recurrence or early metastatic potential in patients with malignant hepatobiliary tumours. The large prospective clinical data base held in the Upper GI surgery department will also be a valuable resource for these projects.

Additional Information

For more information contact tom.hugh@sydney.edu.au

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Keywords

Neuroendocrine tumours, clinical outcomes research, liver metastases, resection

Opportunity ID

The opportunity ID for this research opportunity is: 2848

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