New epidermal growth factor receptor (EGFR) inhibitors for the treatment of cancer

Summary

Molecular modelling and synthesis and characterisation of the hit compounds, biological testing in cell based assays and the determination of the inhibition of receptor dimerisation using gel electrophoresis and Western blotting.

Supervisor(s)

Professor David (Dai) Hibbs

Research Location

Sydney Pharmacy School

Program Type

Masters/PHD

Synopsis

The importance of the over-expression of the EGFR family of receptors in human cancers has been well documented.  This project will build upon a preliminary study performed in our laboratories which involved the design of agents which target EGFR dimerisation (using in silico screening), to generate new hit compounds for biological testing in a range of assays already in place, involving cell proliferation, EGFR dimerisation, and cytotoxicity.  Once again, the successful student will be involved in all aspects of the project, from molecular modelling and synthesis and characterisation of the hit compounds to biological testing in cell based assays and the determination of the inhibition of receptor dimerisation using gel electrophoresis and Western blotting.

Additional Information

  • Are you interested in using your chemistry skills to develop new drugs for the treatment of cancer, psoriasis or ‘superbug’ infections?
 
  • Do you want to be part of a multi-disciplinary team involved in drug discovery? 
Two more projects are available:New agents for the treatment of Pseudomonas aeruginosa infectionsNew human neutrophil elastase (HNE) inhibitors as anti-metastatic agents The exciting opportunities are for Australian / New Zealand students with First Class Honours (or equivalent) undergraduate degrees in Chemistry, Pharmacy or Biochemistry.  Students working on these projects will be closely involved in the design, synthesis and characterisation of these new agents as well as their biological testing and so will develop a wide range of laboratory skills, giving them a head start when applying for jobs in pharmaceutical research / academia. If you are suitably qualified and are interested in any of these research projects, you can also contact Prof. Paul Groundwater (paul.groundwater@sunderland.ac.uk).

Want to find out more?

Contact us to find out what’s involved in applying for a PhD. Domestic students and International students

Contact Research Expert to find out more about participating in this opportunity.

Browse for other opportunities within the Sydney Pharmacy School .

Keywords

EGFR dimerisation, Cancer treatment, Cell proliferation, cytotoxicity

Opportunity ID

The opportunity ID for this research opportunity is: 765

Other opportunities with Professor David (Dai) Hibbs