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Molecular Dynamics of Glutamate Transporters

The aim of this project is to develop a molecular model for the mechanism of glutamate transport and through this we expect to identify novel means of pharmacologically manipulating more...

Supervisor(s): Ryan, Renae (Associate Professor)

Investigating mechanisms of microparticle production by microvascular endothelial cells and defining clinically useful inhibitors

To study the role of microparticles in causing a major complication of malaria infection, namely cerebral malaria. more...

Supervisor(s): Grau, Georges (Professor)

Cellular mechanisms of opioid tolerance and dependence

Tolerance and dependence that contribute to opioid addiction will be studied using patch clamp analyses of cellular and synaptic electrophysiology in brain slices and behavioural co more...

Supervisor(s): Christie, Macdonald (Professor)

Conopeptides as potential pain therapeutics

Dissecting mechanisms of chronic pain using patch clamp analyses of cellular and synaptic electrophysiology in spinal cord slices and behavioural correlations. more...

Supervisor(s): Christie, Macdonald (Professor)

A Novel Approach of Inhibiting Pancreatic Cancer Metastasis via Targeting Tumour Micro-Environment Induced Autophagy

Targeting autophagy and metastasis in pancreatic cancer via NDRG1 Pancreatic Cancer (PC) is highly metastatic with the highest mortality of all cancers (~93%). The pancreatic tu more...

Supervisor(s): Sahni, Sumit (Dr)

Dysregulation of the inflammatory response in diabetes: Its role in poor wound healing

Diabetes is known to alter inflammatroy response but how this contributes to poor wound healing and other complications of diabetes is not known and will be investigated in this wor more...

Supervisor(s): McLennan, Susan (Dr), Shackel, Nicholas (Dr)

Signal processing in the visual system

Research in my laboratory focuses on signal processing in the visual system. I use three methodologies - computational modelling, the analysis of existing neuronal data, and human p more...

Supervisor(s): Freeman, Alan (Dr)

Development of novel anti-cancer metastasis agents derived from omega-3 fatty acid metabolites

At present we have no therapies that prevent cancer spread. In this project we will develop novel w-3 fatty acid epoxide analogues that inhibit tumour metastasis. These derivatives more...

Supervisor(s): Murray, Michael (Professor)

Pharmacological targeting of the metastasis suppressor NDRG1 using novel therapeutics

Metastasis is the major killer in cancer, being extremely difficult to treat. This project will elucidate the molecular mechanisms that initiate and sustain metastatic progression, more...

Supervisor(s): Kovacevic, Zaklina (Dr), Richardson, Des (Professor)

NHMRC Translational Australian Clinical Toxicology (TACT) Program

A range of PhD research project opportunities in human toxicology exist within the TACT program. We are looking for talented and motivated doctoral candidates, with or without a pri more...

Supervisor(s): Buckley, Nicholas (Professor), Dawson, Andrew (Professor)