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Examining the role of ABC transporter proteins in the development of Alzheimer’s disease

Cholesterol and other lipids have been shown to be related to the development of chronic disease including Alzheimer's disease. This project will study aspects of the cellular proce more...

Supervisor(s): Gelissen, Ingrid (Dr)

Pharmacological targeting of sphingosine 1-phosphate receptors to promote remyelination in Alzheimer’s disease and multiple sclerosis

In this project you will investigate a new molecular pathway that is required for normal myelin formation, and the therapeutic potential of targeting this pathway to promote remyeli more...

Supervisor(s): Don, Anthony (Associate Professor)

Neuroimaging Computing for Early Detection of Alzheimer’s Disease

The objective of this program is to investigate multi-modal neuroimaging data, especially the functional neuroimaging, to establish standardized computational methods for image-base more...

Supervisor(s): Cai, Tom Weidong (Associate Professor)

Discovery and validation of new ceramide synthase inhibitors to treat metabolic disease

Ceramide synthase enzyme isoforms 1, 5, and 6, are heavily implicated as drivers of obesity, insulin resistance, and diabetes. Targeting these enzymes is expected to yield new thera more...

Supervisor(s): Don, Anthony (Associate Professor), Qi, Jacob (Dr)

The Microvascular Basis of Alzheimer-like dementias

We are exploring the neuropathology of dementia, with a focus on the role of microvascular degeneration as the precipitating cause of Alzheimer-like dementias. more...

Supervisor(s): Stone, Jonathan (Professor)

Neuroprotection: protecting the central nervous system (retina and brain) from degeneration

Using rodent models and clinical trials, we are exploring strategies to protect the retina and brain from degeneration, in models of age-related macular degeneration, Alzheimer-like more...

Supervisor(s): Stone, Jonathan (Professor)

Molecular Dynamics of Glutamate Transporters

The aim of this project is to develop a molecular model for the mechanism of glutamate transport and through this we expect to identify novel means of pharmacologically manipulating more...

Supervisor(s): Ryan, Renae (Associate Professor)

Towards safe and effective pharmacological care of people with dementia

This research program aims to optimise the prescribing of medications in people with dementia.  more...

Supervisor(s): Tan, Edwin (Dr)