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The Microvascular Basis of Alzheimer-like dementias

We are exploring the neuropathology of dementia, with a focus on the role of microvascular degeneration as the precipitating cause of Alzheimer-like dementias. more...

Supervisor(s): Stone, Jonathan (Professor)

Neuroimaging Computing for Early Detection of Alzheimer’s Disease

The objective of this program is to investigate multi-modal neuroimaging data, especially the functional neuroimaging, to establish standardized computational methods for image-base more...

Supervisor(s): Cai, Tom Weidong (Associate Professor)

The role of a novel mutant gene in dementia and motor neuron disease

We have identified a new gene that when mutated causes dementia and motor neuron disease (MND), diseases that are currently incurable. This project will examine how this mutated gen more...

Supervisor(s): Dobson-Stone, Carol (Dr)

Neuroprotection: protecting the central nervous system (retina and brain) from degeneration

Using rodent models and clinical trials, we are exploring strategies to protect the retina and brain from degeneration, in models of age-related macular degeneration, Alzheimer-like more...

Supervisor(s): Stone, Jonathan (Professor)

Molecular investigations of receptors involved in neurological disorders

The Laboratory of Molecular Neuroscience investigates molecular regulation and drug interactions that occur in receptors associated with neurological diseases. more...

Supervisor(s): Holsinger, Damian (Dr)

Molecular Dynamics of Glutamate Transporters

The aim of this project is to develop a molecular model for the mechanism of glutamate transport and through this we expect to identify novel means of pharmacologically manipulating more...

Supervisor(s): Ryan, Renae (Associate Professor)

ENGINEERED EXTRASYNAPTIC GABAA RECEPTORS: TOWARDS NOVEL ANALGESICS

Recently, there has been an increase of interest in α4δ-containing GABAA receptors as novel drug targets for the design of a new class of analgesics. However, to date th more...

Supervisor(s): Balle, Thomas (Associate Professor), Collins, Mary (Professor)

Understanding mechanisms of action of novel CNS molecules in neurological disorders

Projects involve understanding mechanisms of action of novel CNS molecules in biology more...

Supervisor(s): Collins, Mary (Professor)

Beyond Neuroinflammation: The Role of Microglia in Synaptic Plasticity

Microglia are the immune cells of the brain and are known to respond to infectious and non-infectious insults to the nervous system. Recently, a new function has been demonstrated f more...

Supervisor(s): Graeber, Manuel (Professor)

PET imaging of glioma in a TSPO knockout model

Glioblastoma is the most frequent primary brain tumour and the most malignant glial neoplasm (glioma) with predominantly astrocytic differentiation. Due to their invasive nature, gl more...

Supervisor(s): Graeber, Manuel (Professor), Banati, Richard (Professor)