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Machine learning in cell identity, fate decision, and lineage prediction

Multi-omics and single-cell omics approaches are transforming our understanding of stem cell-based regeneration of tissues and organs on the individual cell level. By generating and more...

Supervisor(s): Yang, Pengyi (Dr)

Regulation of Hematopoietic Stem Cell Production in the Embryo and Adult

In this project we will ask what regulates the appearance and production of hematopoietic stem cells during embryonic development in the mouse and whether these processes also take more...

Supervisor(s): Fraser, Stuart (Dr)

Amino acid sensing mechanisms in human biology.

Amino acid sensing mechanisms determine how dietary protein regulates appetite and satiety, how feeding influences endocrine responses and how nutrition can direct cell fate in brea more...

Supervisor(s): Conigrave, Arthur (Professor)

Control of cell differentiation during mouse embryogenesis and stem cell development

The research will provide insights into how progenitor cells for embryonic tissues may be specified and determine the conditions that promote differentiation into germ layer derivat more...

Supervisor(s): Tam, Patrick (Professor)

Elucidating the neural mechanisms of stress: a 13C-NMR study of glutamate and neuronal-glial interactions

13C-Magnetic Resonance Spectroscopy (13C-MRS) is an emerging imaging modality that allows the measurement of concentrations and synthesis rates of glutamate, glutamine and GABA with more...

Supervisor(s): Lagopoulos, Jim (Associate Professor)

Pathways to therapies in blinding genetic retinal eye diseases

In this project, novel disease genes and variants are identified that cause blinding retinal eye diseases. Cellular, gene editing, proteomic and animal model approaches are taken to more...

Supervisor(s): Jamieson, Robyn (Associate Professor)

Pathways to therapies in blinding genetic retinal eye diseases

In this project, novel disease genes and variants are identified that cause blinding retinal eye diseases. Cellular, gene editing, proteomic and animal model approaches are taken to more...

Supervisor(s): Jamieson, Robyn (Associate Professor)

• Roles of matrix metalloproteinases (MMPs), E-cadherin, beta-catenin, transforming growth factor (TGF-beta), epithelial & endothelial –mesenchymal transition in pathogenesis of kidney fibrosis.

21,000 Australians receive kidney replacement therapy and many more die of kidney failure as a result of kidney fibrosis. TGF-β, a growth factor causing kidney fibrosis, is als more...

Supervisor(s): Zheng, Guoping (Dr), Harris, David (Professor)

• Targeting β-catenin/Foxo to maximize anti-inflammatory and wound healing effects while preventing profibrotic effects of TGF-β as a novel treatment of chronic kidney diseases.

21,000 Australians receive kidney replacement therapy and many more die of kidney failure as a result of kidney fibrosis. TGF-β, a growth factor causing kidney fibrosis, is als more...

Supervisor(s): Zheng, Guoping (Dr), Harris, David (Professor)