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LDL-cholesterol controls the role of integrins in cancer cell migration

This project explores the role of LDL-cholesterol in integrin trafficking and signalling, which is relevant for cancer cell migration. more...

Supervisor(s): Grewal , Thomas (Associate Professor)

Mechanisms of T cell migration and interactions in the tumor microenvironment

The project will use intravital two-photon microscopy to determine the molecules involved in interstitial T cell migration and the molecular mechanisms of T cell interactions with t more...

Supervisor(s): Weninger , Wolfgang (Professor)

Dendritic cells and control of T cell immune responses

DCs are unique antigen-presenting cells that can initiate (prime) CD4 T cell responses, as well as controlling the progression and subsequent reduction of the immune response, devel more...

Supervisor(s): Fazekas, Barbara (Professor)

Characterisation and application of human neural precursor cells in cell-based therapy

Applications of human fetal spinal-cord derived stem cells in cell-based therapy . . . more...

Supervisor(s): Chan-Ling, Tailoi (Professor)

How invasive cancer cells negotiate the 3D tissue environment

My team uses cell biology approaches to discover the cellular machinery that allows deadly, invasive cancer cells to negotiate the surronding 3D environment. more...

Supervisor(s): O'Neill, Geraldine (Associate Professor)

Targeting melanoma secretory pathways.

Cancer cells secrete a variety of factors that induce tumour growth, metastasis, angiogenesis, and alter the tumour stroma to create a more favourable microenviroment. This project more...

Supervisor(s): Weninger , Wolfgang (Professor), Beaumont, Kimberley (Dr)

How do herpes simplex viruses interact with dendritic cells in human skin: clues for vaccine development

Herpes Simplex Virus (HSV) can cause cold sores, genital herpes, keratitis, encephalitis and neonatal herpes. 70-80% of human population is infected with HSV-1 and 22% with HSV-2. O more...

Supervisor(s): Cunningham, Tony (Professor), Kim, Min (Dr)

Developing small molecules that enhance PCSK9/AnxA2 interaction to inhibit PCSK9 and elevate LDLR levels

Statins to decrease low density lipoprotein cholesterol (LDL-C) are a cornerstone to prevent and treat cardiovascular events. However, inadequate dose response, resistance, and seri more...

Supervisor(s): Grewal , Thomas (Associate Professor)

Significance of Osteopontin and its splice variants in alcoholic liver disease

Alcohol induced Opn and Opn isoforms play a role in the progression of alcoholic liver injury mediated via integrin and non-integrin receptor binding. more...

Supervisor(s): Seth, Devanshi (Dr)

Development of novel anti-cancer metastasis agents derived from omega-3 fatty acid metabolites

At present we have no therapies that prevent cancer spread. In this project we will develop novel w-3 fatty acid epoxide analogues that inhibit tumour metastasis. These derivatives more...

Supervisor(s): Murray, Michael (Professor)