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Drug Discovery and Medicinal Chemistry for the Central Nervous System

Projects involve developing novel CNS drugs through applications of organic synthesis, medicinal chemistry and pharmacological screening. more...

Supervisor(s): Kassiou, Michael (Professor)

The role of autoantibodies against neuronal receptors in immune-mediated neurological and psychiatric disorders.

The neuroimmunology group investigates the role of autoimmunity and inflammation of the brain resulting in neurological disturbance in children. Over the last 5-10 years there has b more...

Supervisor(s): Dale, Russell (Professor), Brilot-Turville, Fabienne (Dr)

Search for a cause: the role of astrocytes in the early pathology of Parkinson's disease

The projects in our lab are directed towards finding the cause of Parkinson’s Disease.  In particular we want to know what is the nature of the mechanism that sets the ne more...

Supervisor(s): Allbutt, Haydn (Dr)

Carboranes as unique boron frameworks in medicinal chemistry

Boron-based drugs are increasingly being investigated in many disease categories, with numerous pharmaceutical companies (e.g. GSK, Anacor, and Takeda) dramatically expanding their more...

Supervisor(s): Rendina, Louis (Professor)

Targeting abnormal immune function in the central nervous system to treat cognitive disorders.

There is a growing body of evidence that most neurocognitive disorders, neurodegenerative diseases, and neuropathic pain states involve abnormal immune activity within the central n more...

Supervisor(s): Johnston, Ian (Dr)

Positive effects of exercise on neurological function

There is a growing body of evidence that exercise improves cognitive function and quality of life in a broad range of neurological and neurodegenerative diseases, and accelerates re more...

Supervisor(s): Johnston, Ian (Dr)

Chronic pain & endogenous cannabinoids.

Endogenous cannabinoids represent a potential therapeutic target for intractable pain states, this project will focus on how these agents produce their actions at the cellular level more...

Supervisor(s): Vaughan, Christopher (Dr)

Beyond Neuroinflammation: The Role of Microglia in Synaptic Plasticity

Microglia are the immune cells of the brain and are known to respond to infectious and non-infectious insults to the nervous system. Recently, a new function has been demonstrated f more...

Supervisor(s): Graeber, Manuel (Professor)

Antibody-Mediated Pain Syndrome (AMPS)

Complex regional pain syndromes (CRPSs) are painful disorders with pathophysiological etiologies associated with neuroinflammation, peripheral nerve damage, central sensitization, more...

Supervisor(s): Parratt, John (Dr), Ng, Karl (Associate Professor)

Advanced Instrumentation and Computational Methods for in vivo Molecular Imaging

There are opportunities for physics and engineering graduates to undertake research leading to a PhD with the medical imaging physics group at the University of Sydney node of the N more...

Supervisor(s): Meikle, Steven (Professor)