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Whole genome CRISPR screening to define drug mechanism of action

This project will involve new whole genome CRISPR editing strategies, coupled with bioinformatics analysis, to identify the complete molecular mechanism of action for relevant human more...

Supervisor(s): Neely, Greg (Professor)

CRISPR-based genome editing

The recent development of genome editing technology is perhaps the single biggest technical breakthrough in the history of life sciences, allowing for near complete control over euk more...

Supervisor(s): Neely, Greg (Professor)

HUMAN MINIBRAINS GROWN FROM STEM CELLS

This project will involve CRISPR genome editing strategies combined with human stem cell derived mini-brains to investigate new neuronal factors that control development, cognitive more...

Supervisor(s): Neely, Greg (Professor)

Using Gene editing to cure genetic neurological disorders

This project is an opportunity for a PhD student who is interested in genetic disorders of the brain and who is prepared to work at the cutting edge of technology. Genetic neurologi more...

Supervisor(s): Gold, Wendy (Dr)

Gene editing of stem cells or cancer to develop new stem cell therapies to treat human disease

This project involves the use of human stem cells and CRISPR genome editing to study basic signalling pathways controlling stem cell differentiation and/or cancer. A compliment more...

Supervisor(s): Neely, Greg (Professor)

Gene editing of human stem cells and to better understand chronic pain disease

This project involves the use of human stem cells to generate pain sensing neurons and CRISPR gene editing to identify new pain killers. A complimentary scholarship for this pr more...

Supervisor(s): Neely, Greg (Professor)

Gene function and RNA processing in gut endoderm development

This project aims to unravel the impact of RNA processing on the function the targets of a RNA binding protein in the development of the embryonic gut and the associated organs. more...

Supervisor(s): Fossat, Nicolas (Dr), Tam, Patrick (Professor)

The DNA replication stress response

Genome integrity in human cells is maintained through the coordinated functions of the DNA damage response. We study these processes with particular interest in the pathways that re more...

Supervisor(s): Cesare, Tony (Dr)

Gene and Cell therapy for treating corneal diseases

Two research projects existing under this board area :1. Develop in vivo gene editing technique to treat corneal diseases; and 2. Sequencing and mapping gene and protein interaction more...

Supervisor(s): You, Jingjing (Dr), Sutton, Gerard (Professor)

Investigating the links between telomerase and the DNA damage response in cancer cells

The ribonucleoprotein enzyme telomerase counteracts telomere shortening in a majority of cancers, allowing for unlimited cell division. Most normal cells do not express telomerase, more...

Supervisor(s): Bryan, Tracy (Professor)