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Molecular Dynamics of Glutamate Transporters

The aim of this project is to develop a molecular model for the mechanism of glutamate transport and through this we expect to identify novel means of pharmacologically manipulating more...

Supervisor(s): Ryan, Renae (Associate Professor)

Informatics and Bioinformatics-based Approaches to Protein-Ligand Interaction

The principles of soluble protein structure and ligand docking are applied to structure analysis of membrane bound protein receptors and receptor ligand complexes. more...

Supervisor(s): Church, W Bret (Dr)

Medicinal and Pharmaceutical Chemistry — Design, Synthesis and Testing of New Anti-Bacterial Agents

This project would appeal to those with interests in pharmaceutical applications of medicinal and protein chemistry. more...

Supervisor(s): Groundwater, Paul (Professor), Church, W Bret (Dr), Hibbs, David (Dai) (Professor)

Structure-based drug design with Soluble Epoxide Hydrolase

Soluble Epoxide Hydrolase (sEH), and more importantly its inhibition, may form the basis of a number of therapies due to anti-inflammatory more...

Supervisor(s): Church, W Bret (Dr)

Understanding the Switch between Enzyme and Signaling Behaviours in Human Group IIA Secreted Phospholipase A2 by Inhibitory Intervention

The principles of soluble protein structure and ligand docking are applied to structure analysis of membrane bound protein receptors and receptor ligand complexes. more...

Supervisor(s): Church, W Bret (Dr)

Structural and Magnetic Properties of 4d Oxides

How high can magnetic interactions go?  Using second and third row transition metal oxides we are targeting a class of perovskite materials that could potentially have the high more...

Supervisor(s): Kennedy, Brendan (Professor)

The HAMLET molecular species with anticancer properties

We are interested to determine how the anti-cancer properties of this family of molecules can be translated into cancer treatment. We believe there may be a delivery system which n more...

Supervisor(s): Church, W Bret (Dr)

ENGINEERED EXTRASYNAPTIC GABAA RECEPTORS: TOWARDS NOVEL ANALGESICS

Recently, there has been an increase of interest in α4δ-containing GABAA receptors as novel drug targets for the design of a new class of analgesics. However, to date th more...

Supervisor(s): Balle, Thomas (Associate Professor), Collins, Mary (Professor)

Function and regulation of P-type ATPase ion pumps

The project aims to understand at the atomic level how the Na+,K+-ATPase and related ion pumps function and how they are regulated. more...

Supervisor(s): Clarke, Ron (Associate Professor)

How do gingipains recognise their host cell targets?

Porphyromonas gingivalis is a gram-negative, rod-shaped anaerobic pathogenic bacterium that found in the oral cavity. more...

Supervisor(s): Collyer, Charles (Associate Professor)