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Regulation of host resistance and immune response to human pathogens

The laboratory of Immunology and Host Defense focuses on the immune mechanisms that regulate host resistance to pathogens of global importance. It currently offers multiple projects more...

Supervisor(s): Feng, Carl (Dr)

Targeting abnormal immune function in the central nervous system to treat cognitive disorders.

There is a growing body of evidence that most neurocognitive disorders, neurodegenerative diseases, and neuropathic pain states involve abnormal immune activity within the central n more...

Supervisor(s): Johnston, Ian (Dr)

Chemotherapy-induced neuropathic pain, fatigue, and cognitive impairments

Cancer and cancer treatments are associated with a wide range of side effects, including those of the nervous system. These present as neuropathic pain, fatigue, and cognitive impai more...

Supervisor(s): Johnston, Ian (Dr)

Studies of Initial innate immune responses to Herpes Simplex Virus in human skin guide vaccine development.

To join an experienced team of researchers in the Westmead Millennium Institute to study the human immunology of Herpes Simplex Virus (HSV) to facilitate vaccine development. Such a more...

Supervisor(s): Cunningham, Tony (Professor), Kim, Min (Dr)

Asthma: Young adult self management

This project will employ illness narrative qualitative research methods, and video and audio recordings of young Australians who are living with asthma. The work follows on fro more...

Supervisor(s): Smith, Lorraine (Dr), Armour, Carol (Professor)

VZV interactions with human ganglionic cells

Varicella zoster virus interactions with human ganglionic cells more...

Supervisor(s): Abendroth, Allison (Associate Professor)

Understanding the Switch between Enzyme and Signaling Behaviours in Human Group IIA Secreted Phospholipase A2 by Inhibitory Intervention

The principles of soluble protein structure and ligand docking are applied to structure analysis of membrane bound protein receptors and receptor ligand complexes. more...

Supervisor(s): Church, W Bret (Dr)

An investigation into the mechanisms of immune evasion in metastatic melanoma patients treated with molecular or immune checkpoint inhibitors.

The aim of this project is to characterise the immune reaction and prevalence of immune inhibitory mechanisms present in metastatic melanoma patient tumours whilst on immune checkpo more...

Supervisor(s): Scolyer, Richard (Professor), Long, Georgina (Professor)

How do gingipains recognise their host cell targets?

Porphyromonas gingivalis is a gram-negative, rod-shaped anaerobic pathogenic bacterium that found in the oral cavity. more...

Supervisor(s): Collyer, Charles (Associate Professor)

Interactions between porcine ligands and the human lymphocyte activating receptor NKG2D

Role of NKG2D in the human cellular immune response against porcine xenotransplants. more...

Supervisor(s): Sharland, Alexandra (Dr)