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Discovery and Development of Allosteric Modulators of Glycine Transporters and Glycine Receptors for the Treatment of Chronic Pain

We offer a variety projects around the discovery and development of new allosteric modulators of glycine transporters and receptors for the treatment of chronic pain. We use a compr more...

Supervisor(s): Vandenberg, Robert (Professor)

Understanding ageing of the endothelium

The investigations are focussed on identifying the biological and molecular changes that occur when endothelial cells undergo senescence (ageing) and the impact on disease such as d more...

Supervisor(s): Gamble, Jennifer (Professor)

Regulatory Proteins in Development and Disease

PhD projects in this laboratory are focused on understanding how key proteins can lead to both normal development and disease, and using this knowledge to develop reagents to inhibi more...

Supervisor(s): Matthews, Jacqueline (Professor)

Antibody-Mediated Pain Syndrome (AMPS)

Complex regional pain syndromes (CRPSs) are painful disorders with pathophysiological etiologies associated with neuroinflammation, peripheral nerve damage, central sensitization, more...

Supervisor(s): Parratt, John (Dr), Ng, Karl (Associate Professor)

Phosphoproteomics in early T-cell signalling

Using phospho-proteomics to understand T-cell signalling/signal transduction. more...

Supervisor(s): Manolios, Nicholas (Professor)

Molecular Dynamics of Glutamate Transporters

The aim of this project is to develop a molecular model for the mechanism of glutamate transport and through this we expect to identify novel means of pharmacologically manipulating more...

Supervisor(s): Ryan, Renae (Associate Professor)

THE USE OF MARIJUANA AND/OR ENDOCANNABINOID OILS FOR THE TREATMENT OF OSTEOARTHRITIS (OA)

Pre-clinical studies for the effects of CBD and analogues for the treatment of osteoarthritis more...

Supervisor(s): Manolios, Nicholas (Professor), Arnold, Jonathon (Associate Professor)

Towards a cure for Type I diabetes mellitus

Transfect a lentivirus construct expressing an immunosuppressive peptide in islet cells for the treatment of diabetes type I more...

Supervisor(s): Manolios, Nicholas (Professor), Logan, Grant (Dr)

Post-translational modifications in bacterial proteins

This project will identify novel proteins that are post-translationally modified in bacterial pathogens and the role of such modification in virulence. more...

Supervisor(s): Cordwell, Stuart (Professor)

Phosphate homeostasis and fungal virulence

Inorganic phosphate (Pi) is an important macronutrient for all living organisms including yeast, and is essential for ATP, phospholipid and protein synthesis, metabolism and signall more...

Supervisor(s): Djordjevic, Julianne (Dr), Sorrell, Tania (Professor)