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Generation of a sheep model of Batten disease using the CRISPR/Cas9 genome editing system

The neuronal ceroid lipofuscinoses (NCLs, Batten disease) are a group of fatal neurodegenerative inherited diseases in humans and animals (http://bdsra.org/). There is no cure, but more...

Supervisor(s): Tammen, Imke (Associate Professor), Grupen, Christopher Gerald (Associate Professor)

Whole genome CRISPR screening to define drug mechanism of action

This project will involve new whole genome CRISPR editing strategies, coupled with bioinformatics analysis, to identify the complete molecular mechanism of action for relevant human more...

Supervisor(s): Neely, Greg (Professor)

HUMAN MINIBRAINS GROWN FROM STEM CELLS

This project will involve CRISPR genome editing strategies combined with human stem cell derived mini-brains to investigate new neuronal factors that control development, cognitive more...

Supervisor(s): Neely, Greg (Professor)

Gene therapy for genetic and acquired diseases of the liver and haematopoietic system.

We are working on developing new therapies for the treatment of genetic and acquired diseases of the liver and haematopoietic system. The Gene Therapy Research Unit has a diverse se more...

Supervisor(s): Alexander, Ian (Professor), Ginn, Samantha (Dr), Logan, Grant (Dr)

The DNA replication stress response

Genome integrity in human cells is maintained through the coordinated functions of the DNA damage response. We study these processes with particular interest in the pathways that re more...

Supervisor(s): Cesare, Tony (Dr)

Pathways to therapies in blinding genetic retinal eye diseases

In this project, novel disease genes and variants are identified that cause blinding retinal eye diseases. Cellular, gene editing, proteomic and animal model approaches are taken to more...

Supervisor(s): Jamieson, Robyn (Associate Professor)

Pathways to therapies in blinding genetic retinal eye diseases

In this project, novel disease genes and variants are identified that cause blinding retinal eye diseases. Cellular, gene editing, proteomic and animal model approaches are taken to more...

Supervisor(s): Jamieson, Robyn (Associate Professor)

Genomic medicine for unravelling the challenges of pathogenesis and treatment of blindness due to childhood cataract and glaucoma

Novel disease genes and variants are identified that contribute to the blinding eye diseases of childhood cataract and glaucoma.  In this project further novel variants will be more...

Supervisor(s): Jamieson, Robyn (Associate Professor)

Towards a cure for Type I diabetes mellitus

Transfect a lentivirus construct expressing an immunosuppressive peptide in islet cells for the treatment of diabetes type I more...

Supervisor(s): Manolios, Nicholas (Professor), Logan, Grant (Dr)

RESEARCH OPPORTUNITIES IN BIOETHICS

Associate Professor Ainsley Newson is Deputy Director and an Associate Professor in Bioethics at Sydney Health Ethics, Sydney School of Public Health. She has degree qualifications more...

Supervisor(s): Newson, Ainsley (Associate Professor)