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Obesity and insulin resistance in children and adolescents.

Studies on various aspects of obesity and insulin resistance in children and young people - covering management, prevention and pathophysiology. There is potential for a range of di more...

Supervisor(s): Baur, Louise (Professor), Garnett, Sarah (Dr), Cowell, Chris (Professor)

Characterising insulin secretory granules as a function of age

In β-cells, insulin is stored in secretory granules (SGs). Upon stimulation, these SGs deliver insulin to the bloodstream. It is known that SGs exist in two functionally distin more...

Supervisor(s): Kebede, Melkam (Dr)

Discovery and validation of new ceramide synthase inhibitors to treat metabolic disease

Ceramide synthase enzyme isoforms 1, 5, and 6, are heavily implicated as drivers of obesity, insulin resistance, and diabetes. Targeting these enzymes is expected to yield new thera more...

Supervisor(s): Don, Anthony (Associate Professor), Qi, Jacob (Dr)

Diabetes and beta-cell gene expression

Diabetes develops when the insulin secreting beta-cells in the pancreas can no longer release enough insulin to control blood glucose concentrations. This often occurs in the settin more...

Supervisor(s): Gunton, Jenny (Professor)

Treating obesity by activating beige and brown fat; human transplant studies

Obesity occurs when energy intake exceeds energy expenditure. Current treatments for obesity are largely ineffective, and two-thirds of Australian adults are now overweight or obese more...

Supervisor(s): Gunton, Jenny (Professor)

Characterising changes in a proteome of islets and islet cell types during progression to type 2 diabetes

Characterizing changes in a proteome through pathogenesis of diseases can provide unparalleled insights into the mechanisms underpinning disease. In this project, using flow cytomet more...

Supervisor(s): Kebede, Melkam (Dr)

The effect of simulated shift work on food desirability and metabolism

The aim of this research is to ascertain the impact of a simulated night shift rotation on food desirability in order to increase our understanding of the mechanisms that underpin i more...

Supervisor(s): Phillips, Craig (Dr), Comas Soberats, Maria (Dr)

Dietary effects to the local immune response and the initiation and propagation of diabetes and cardiovascular disease in mice

Background: Longitudinal studies have demonstrated a two-¬way relationship between diabetes and the local inflammatory host response, e.g. periodontitis, with more severe period more...

Supervisor(s): Eberhard, Joerg (Professor)

RNA-based biomarkers to understand and predict disease progression

RNA-based biomarkers are becoming increasingly important due to their stability and sensitivity of detection. This project will use in vitro, in vivo and clinical sample analysis b more...

Supervisor(s): Hardikar, Anandwardhan (Associate Professor)

The fetal environment, pregnancy, and cardiovascular risk.

Opportunity exists for research higher degree study on projects related to the fetal environment, pregnancy and cardiovascular risk. These potentially include epidemiological analys more...

Supervisor(s): Skilton, Michael (Dr)