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Molecular dynamics simulations of ion channels and transporters

Understanding the function of ion channels and transporters using molecular dynamics simulations more...

Supervisor(s): Kuyucak, Serdar (Associate Professor)

Regulation of ion transport in the respiratory epithelium in health and disease

The project will focus on elucidating the mechanisms by which respiratory pathogens including influenza, parainfluenza, avian influenza (H5N1) viruses, and microbacterium tuberculos more...

Supervisor(s): Cook, David I (Professor)

Develop single-cell mechanobiological methods for discovering molecular mechanisms of cardiovascular and neuronal mechanical force sensing

We are developing cutting-edge technologies for the following biomedical application: 1) define the mechanosensing functions of key protein players in the cardiovascular system such more...

Supervisor(s): Ju, Lining (Arnold) (Dr)

Chronic pain & endogenous cannabinoids.

Endogenous cannabinoids represent a potential therapeutic target for intractable pain states, this project will focus on how these agents produce their actions at the cellular level more...

Supervisor(s): Vaughan, Christopher (Dr)

Precision medicines for GABA-A receptor variants in epilepsy

Developmental and Epileptic Encephalopathies (DEEs) are rare and severe neurological conditions often associated with intellectual disability, developmental delay, autism spectrum d more...

Supervisor(s): Collins, Mary (Professor)

Phosphoproteomics in early T-cell signalling

Using phospho-proteomics to understand T-cell signalling/signal transduction. more...

Supervisor(s): Manolios, Nicholas (Professor)

THE USE OF MARIJUANA AND/OR ENDOCANNABINOID OILS FOR THE TREATMENT OF OSTEOARTHRITIS (OA)

Pre-clinical studies for the effects of CBD and analogues for the treatment of osteoarthritis more...

Supervisor(s): Manolios, Nicholas (Professor), Arnold, Jonathon (Associate Professor)

Towards a cure for Type I diabetes mellitus

Transfect a lentivirus construct expressing an immunosuppressive peptide in islet cells for the treatment of diabetes type I more...

Supervisor(s): Manolios, Nicholas (Professor), Logan, Grant (Dr)

Neuroscience/Neuroimmunology Research: Role of antibody in brain immune-mediated diseases

The Institute of Neuromuscular Research (INMR) is part of the Children's Hospital at Westmead (CHW), the largest paediatric centre in NSW, providing the most advanced care and treat more...

Supervisor(s): Brilot-Turville, Fabienne (Dr), Dale, Russell (Professor)

Informatics and Bioinformatics-based Approaches to Protein-Ligand Interaction

The principles of soluble protein structure and ligand docking are applied to structure analysis of membrane bound protein receptors and receptor ligand complexes. more...

Supervisor(s): Church, W Bret (Dr)