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Novel therapy to prevent and treat kidney fibrosis

Progressive kidney disease is a global health burden most commonly caused by diabetes and obesity, which are dramatically on the rise. In Australia, 1 in 3 adults are at risk of dev more...

Supervisor(s): Saad, Sonia (Dr), Pollock, Carol (Professor)

• Roles of matrix metalloproteinases (MMPs), E-cadherin, beta-catenin, transforming growth factor (TGF-beta), epithelial & endothelial –mesenchymal transition in pathogenesis of kidney fibrosis.

21,000 Australians receive kidney replacement therapy and many more die of kidney failure as a result of kidney fibrosis. TGF-β, a growth factor causing kidney fibrosis, is als more...

Supervisor(s): Zheng, Guoping (Dr), Harris, David (Professor)

• Targeting β-catenin/Foxo to maximize anti-inflammatory and wound healing effects while preventing profibrotic effects of TGF-β as a novel treatment of chronic kidney diseases.

21,000 Australians receive kidney replacement therapy and many more die of kidney failure as a result of kidney fibrosis. TGF-β, a growth factor causing kidney fibrosis, is als more...

Supervisor(s): Zheng, Guoping (Dr), Harris, David (Professor)

Interplay between Innate and adaptive immunity in kidney ischemia reperfusion injury and allograft rejection

This study is to investigate the link between innate and adaptive immunity in kidney ischemia reperfusion injury and allograft rejection with a view to identifying new therapeutic t more...

Supervisor(s): Chadban, Steve (Professor), Wu, Huiling (Associate Professor)

Identifying the causes of fibrosis after kidney transplantation

This is a PhD project. The successful applicant will be top up scholarship. This study will lead to publish high quality of papers and apply a new NHMRC project grant. more...

Supervisor(s): O'Connell, Philip (Professor)

The role of key driver genes in the pathogenesis of acute renal allograft rejection

This is a PhD project. The successful applicant will be top up scholarship. This study will lead to publish high quality of papers and apply a new NHMRC project grant. more...

Supervisor(s): O'Connell, Philip (Professor), Hu, Min (Dr)

Interactions between porcine ligands and the human lymphocyte activating receptor NKG2D

Role of NKG2D in the human cellular immune response against porcine xenotransplants. more...

Supervisor(s): Sharland, Alexandra (Dr)

Tubular autophagy in diabetic nephropathy

The central aim of the project is to define the role of autophagy dysfunction leading to renal tubulointerstitial fibrosis in diabetic nephropathy. more...

Supervisor(s): Pollock, Carol (Professor), Chen, Xin-Ming (Dr)

The role of miRNAs in diabetic renal interstitial fibrosis

The central aim of the project is to define the therapeutic benefit of targeting miRNAs in renal interstitial fibrosis in diabetic nephropathy. more...

Supervisor(s): Pollock, Carol (Professor), Chen, Xin-Ming (Dr)