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Investigating novel molecular mechanisms in motor neuron disease.

This project will use molecular and cell biology approaches to investigate known and novel motor neuron disease genes and the functional consequences of disease causing mutations. more...

Supervisor(s): Nicholson, Garth (Professor)

Muscle specific kinase in synaptic adaptation

This project will investigate the role of postsynaptic Muscle specific Kinase (MuSK) in regulating presynaptic neurotransmitter release at the neuromuscular junction. more...

Supervisor(s): Phillips, William (Bill) (Associate Professor), Protti, Dario (Dr)

Cannabinoid regulation of neuromuscular transmission

Cannabinoid drugs are under active consideration for treatment of a wide range of health conditions. This electrophysiology project will investigate the influence of specific endoca more...

Supervisor(s): Phillips, William (Bill) (Associate Professor), Protti, Dario (Dr)

Cellular mechanisms of opioid tolerance and dependence

Tolerance and dependence that contribute to opioid addiction will be studied using patch clamp analyses of cellular and synaptic electrophysiology in brain slices and behavioural co more...

Supervisor(s): Christie, Macdonald (Professor)

Conopeptides as potential pain therapeutics

Dissecting mechanisms of chronic pain using patch clamp analyses of cellular and synaptic electrophysiology in spinal cord slices and behavioural correlations. more...

Supervisor(s): Christie, Macdonald (Professor)

How do molecules make memories? Understanding synaptic plasticity at the level of protein pathways and signalling.

This project aims to discover and validate new molecular mechanisms of how synaptic plasticity, which underlies learning and memory, is regulated by protein interactions and phospho more...

Supervisor(s): Graham, Mark (Dr)

Molecular Dynamics of Glutamate Transporters

The aim of this project is to develop a molecular model for the mechanism of glutamate transport and through this we expect to identify novel means of pharmacologically manipulating more...

Supervisor(s): Ryan, Renae (Associate Professor)

Determining the functional significance of non-coding DNA variants in genes for complex traits involving gene-environmental interactions

To identify non-protein coding DNA changes in genes that interact with the environment using 2 models – sporadic amyotrophic lateral sclerosis for the vulnerability to environ more...

Supervisor(s): Yu, Bing (Associate Professor)

Implant electrode optimisation and neurolinguistics

The benefit provided by additional electrodes in medical implants is currently unknown. A typical cochlear implant only contains 12-22 electrodes to stimulate about 30,000 more...

Supervisor(s): McEwan, Alistair (Professor)

Brain Network Structure and Dynamics

This research area is concerned with developing better understanding of the structure of the brain, especially through modeling the dynamics and interactions of its neuronal network more...

Supervisor(s): Robinson, Peter (Professor)