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Chronic pain & endogenous cannabinoids.

Endogenous cannabinoids represent a potential therapeutic target for intractable pain states, this project will focus on how these agents produce their actions at the cellular level more...

Supervisor(s): Vaughan, Christopher (Dr)

Conopeptides as potential pain therapeutics

Dissecting mechanisms of chronic pain using patch clamp analyses of cellular and synaptic electrophysiology in spinal cord slices and behavioural correlations. more...

Supervisor(s): Christie, Macdonald (Professor)

Chemotherapy-induced neuropathic pain, fatigue, and cognitive impairments

Cancer and cancer treatments are associated with a wide range of side effects, including those of the nervous system. These present as neuropathic pain, fatigue, and cognitive impai more...

Supervisor(s): Johnston, Ian (Dr)

Positive effects of exercise on neurological function

There is a growing body of evidence that exercise improves cognitive function and quality of life in a broad range of neurological and neurodegenerative diseases, and accelerates re more...

Supervisor(s): Johnston, Ian (Dr)

Targeting abnormal immune function in the central nervous system to treat cognitive disorders.

There is a growing body of evidence that most neurocognitive disorders, neurodegenerative diseases, and neuropathic pain states involve abnormal immune activity within the central n more...

Supervisor(s): Johnston, Ian (Dr)

ENGINEERED EXTRASYNAPTIC GABAA RECEPTORS: TOWARDS NOVEL ANALGESICS

Recently, there has been an increase of interest in α4δ-containing GABAA receptors as novel drug targets for the design of a new class of analgesics. However, to date th more...

Supervisor(s): Balle, Thomas (Associate Professor), Collins, Mary (Professor)