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GENE THERAPY FOR GENETIC BONE DISEASES

Gene therapy is becoming a practical approach to treat severe genetic conditions and in recent years conditions such as Spinal Muscular Atrophy (SMA) have been success stories. Our more...

Supervisor(s): Schindeler, Aaron (Associate Professor), Munns, Craig (Associate Professor)

UNDERSTANDING GENETIC VARIATIONS IN BONE

Functional genomics is a field that is undergoing major changes in practice due to the accessibility of gene editing technologies. Our team has developed methods for gene editing in more...

Supervisor(s): Schindeler, Aaron (Associate Professor), Munns, Craig (Associate Professor)

Development of Tissue-Targeted Vectors for Musculoskeletal Gene Therapy

A unique opportunity is available for an outstanding PhD scholar to conduct research in developing tissue-targeted AAV vectors for gene delivery and CRISPR gene editing. more...

Supervisor(s): Schindeler, Aaron (Associate Professor)

PRECLINICAL AND CLINICAL DEVELOPMENT OF NOVEL BONE-BINDING ANTIMICROBIALS

Our team has spent several years developing and testing new a new class of drugs termed bone-binding antimicrobials (BBAs). Our lead compound (BBA-1) has been shown to have antimicr more...

Supervisor(s): Schindeler, Aaron (Associate Professor), Little, David (Professor)

Strategies for Building Bone

This project will investigate the use of biological agents in stimulating bone growth and inhibiting bone resorption. more...

Supervisor(s): Zreiqat, Hala (Professor)

Surface modification of biomaterials for orthopaedic applications

This project will establish that our novel modified calcium silicate materials have enhanced bioactivity and osseointegration properties for coatings onto orthopaedic implants. more...

Supervisor(s): Zreiqat, Hala (Professor)

Scaffolds for skeletal tissue regeneration

This project will modify calcium silicate ceramic scaffolds with divalent cations to improve their mechanical, osteoinductive and osteoconductive properties for bone regeneration. more...

Supervisor(s): Zreiqat, Hala (Professor)

Role of S100A8 and S100A9 in osteoarthritis

This projects involves the development of novel scaffolds and biomaterials for bone and cartilage regeneration. more...

Supervisor(s): Zreiqat, Hala (Professor)