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Informatics and Bioinformatics-based Approaches to Protein-Ligand Interaction

The principles of soluble protein structure and ligand docking are applied to structure analysis of membrane bound protein receptors and receptor ligand complexes. more...

Supervisor(s): Church, W Bret (Dr)

Function and regulation of P-type ATPase ion pumps

The project aims to understand at the atomic level how the Na+,K+-ATPase and related ion pumps function and how they are regulated. more...

Supervisor(s): Clarke, Ron (Associate Professor)

Discovery and Development of Allosteric Modulators of Glycine Transporters and Glycine Receptors for the Treatment of Chronic Pain

We offer a variety projects around the discovery and development of new allosteric modulators of glycine transporters and receptors for the treatment of chronic pain. We use a compr more...

Supervisor(s): Vandenberg, Robert (Professor)

Medicinal and Pharmaceutical Chemistry — Design, Synthesis and Testing of New Anti-Bacterial Agents

This project would appeal to those with interests in pharmaceutical applications of medicinal and protein chemistry. more...

Supervisor(s): Groundwater, Paul (Professor), Church, W Bret (Dr), Hibbs, David (Dai) (Professor)

Computational investigation of high affinity ligand binding to proteins

Design of high-affinity ligands for protein targets using docking, molecular dynamics simulations and quantitative structure-activity relations. more...

Supervisor(s): Kuyucak, Serdar (Associate Professor)

Molecular Dynamics of Glutamate Transporters

The aim of this project is to develop a molecular model for the mechanism of glutamate transport and through this we expect to identify novel means of pharmacologically manipulating more...

Supervisor(s): Ryan, Renae (Associate Professor)

Organic and Supramolecular Chemistry

The synthesis of cyclic peptides and derivatives is currently of significant interest, due to their potential applications in a range of areas spanning both chemistry and biology. N more...

Supervisor(s): Jolliffe, Katrina (Kate) (Professor)

From the molecular study of receptor-ligand interactions to novel biomarkers of disease and non-invasive brain imaging - opportunities in basic and clinically oriented research

Methodologically broad but thematically focused on the role of receptors in glial (non-neuronal) cells in brain disease, the available basic science projects are concerned with the more...

Supervisor(s): Banati, Richard (Professor)

Understanding ageing of the endothelium

The investigations are focussed on identifying the biological and molecular changes that occur when endothelial cells undergo senescence (ageing) and the impact on disease such as d more...

Supervisor(s): Gamble, Jennifer (Professor)

Post-translational modifications in bacterial proteins

This project will identify novel proteins that are post-translationally modified in bacterial pathogens and the role of such modification in virulence. more...

Supervisor(s): Cordwell, Stuart (Professor)