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Informatics and Bioinformatics-based Approaches to Protein-Ligand Interaction

The principles of soluble protein structure and ligand docking are applied to structure analysis of membrane bound protein receptors and receptor ligand complexes. more...

Supervisor(s): Church, W Bret (Dr)

Investigating the role of a novel RNA binding protein in telomerase activity

We have identified a role for a novel RNA binding protein in telomerase biogenesis and recruitment to telomeres. We aim to investigate how this protein functions in this context usi more...

Supervisor(s): Pickett, Hilda (Associate Professor)

Atomic structure, assembly, interactions and engineering of functional amyloids

This project aims to engineer hydrophobins for a range of biotechnological applications from coating of medical implants to formulation of drug delivery vehicles. The work includes more...

Supervisor(s): Kwan, Ann (Dr)

Proteomic Mapping and Molecular Modelling of Avian H5N1 Influenza Antigen Epitopes Targeted by Human Antibodies

In studying Avian H5N1 Influenza specific Antibodies within Humans the aim is to clearly and definitively identify the respective viral proteins and epitopes targeted by neutralizin more...

Supervisor(s): Lynch, Garry (Dr)

The substitution and formation of red-shifted chlorophylls

Novel pigments and new directions in photosynthesis: past, now and future more...

Supervisor(s): Chen, Min (Professor)

How do gingipains recognise their host cell targets?

Porphyromonas gingivalis is a gram-negative, rod-shaped anaerobic pathogenic bacterium that found in the oral cavity. more...

Supervisor(s): Collyer, Charles (Associate Professor)

Understanding ageing of the endothelium

The investigations are focussed on identifying the biological and molecular changes that occur when endothelial cells undergo senescence (ageing) and the impact on disease such as d more...

Supervisor(s): Gamble, Jennifer (Professor)

‘Magic Bullet’ Cancer Drugs and Antibiotics

We are building new kinds of cancer drugs and antibiotics: molecules that change their behaviour in the presence of their biological target, being chemically activated only when the more...

Supervisor(s): Rutledge, Peter (Professor)

Biochemistry and cell biology of the cancer-associated enzyme telomerase

Telomerase is the enzyme responsible for lengthening the ends of chromosomes (telomeres), thereby allowing most cancer cells to divide indefinitely.  We are determining the mec more...

Supervisor(s): Bryan, Tracy (Associate Professor), Cohen, Scott (Dr)

Function and regulation of P-type ATPase ion pumps

The project aims to understand at the atomic level how the Na+,K+-ATPase and related ion pumps function and how they are regulated. more...

Supervisor(s): Clarke, Ron (Associate Professor)