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Sorting proinsulin into secretory vesicles

Reduction in glucose-stimulated mature insulin secretion and increased constitutive and regulated secretion of proinsulin are characteristics of β-cell failure. This may be due more...

Supervisor(s): Kebede, Melkam (Dr)

Dysferlin and defective membrane repair in muscular dystrophy

We are studying a form of muscular dystrophy caused by deficiency of the protein dysferlin. Dysferlin patients have a primary defect in skeletal muscle membrane repair, and are unab more...

Supervisor(s): Cooper, Sandra (Dr)

Targeting melanoma secretory pathways.

Cancer cells secrete a variety of factors that induce tumour growth, metastasis, angiogenesis, and alter the tumour stroma to create a more favourable microenviroment. This project more...

Supervisor(s): Weninger , Wolfgang (Professor), Beaumont, Kimberley (Dr)