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Structure-based drug design with Kynurenine Aminotransferase-I

Human kynurenine amino transferase (KAT-1) forms the basis of a structure-based drug design study with implications for schizophrenia. more...

Supervisor(s): Church, W Bret (Dr)

Structure-based drug design with Soluble Epoxide Hydrolase

Soluble Epoxide Hydrolase (sEH), and more importantly its inhibition, may form the basis of a number of therapies due to anti-inflammatory more...

Supervisor(s): Church, W Bret (Dr)

Drug Discovery and Medicinal Chemistry for the Central Nervous System

Projects involve developing novel CNS drugs through applications of organic synthesis, medicinal chemistry and pharmacological screening. more...

Supervisor(s): Kassiou, Michael (Professor)

Computational investigation of high affinity ligand binding to proteins

Design of high-affinity ligands for protein targets using docking, molecular dynamics simulations and quantitative structure-activity relations. more...

Supervisor(s): Kuyucak, Serdar (Associate Professor)

Informatics and Bioinformatics-based Approaches to Protein-Ligand Interaction

The principles of soluble protein structure and ligand docking are applied to structure analysis of membrane bound protein receptors and receptor ligand complexes. more...

Supervisor(s): Church, W Bret (Dr)

Understanding the Switch between Enzyme and Signaling Behaviours in Human Group IIA Secreted Phospholipase A2 by Inhibitory Intervention

The principles of soluble protein structure and ligand docking are applied to structure analysis of membrane bound protein receptors and receptor ligand complexes. more...

Supervisor(s): Church, W Bret (Dr)

Chemical synthesis and phenotypic validation of precision proteolysis targeted chimeras (PROTACs) for cancer and cardiovascular disease

Emerging from the interface between chemistry and biology, chemical biology has led to the establishment of several game-changing drug discovery paradigms. Among these revolutionary more...

Supervisor(s): Liu, Xuyu (Dr), Payne, Richard (Professor)