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Red blood cell enucleation

Prior to entering the blood stream, developing erythroid or red blood cells condense and expel their nucleus. This unusual process occurs millions of times per minute in a healthy a more...

Supervisor(s): Fraser, Stuart (Dr)

A novel regulatory pathway affecting red cell and platelet phenotype

A novel mutation has been identified in an Australian family with a combined defect in platelet and red cell function. This project will explore the molecular mechanism of this defe more...

Supervisor(s): Ward, Chris (Professor)

Link between ATP supply and consumption in the maintenance of the shape of the red blood cell in normal and disease states

The link between the main energy supply (ATP from glycolysis) and its consumption by the cytoskeleton will be studied by using nuclear magnetic resonance (NMR) spectroscopy, compute more...

Supervisor(s): Kuchel, Philip (Emeritus Professor)

Mechanosensation in human erythrocytes: NMR and microscopy studies

We/you will explore the mechanistic basis of the autonomous movement of the plasma membrane of red blood cells, so called membrane flickering. Also, the molecular processes that und more...

Supervisor(s): Kuchel, Philip (Emeritus Professor)

Implantable Medical Devices

The ability to attach functional proteins, antibodies and enzymes to surfaces underpins the development of the next generation of implantable medical devices, biosensors and protein more...

Supervisor(s): Bilek, Marcela (Professor)

Inhertied and acquired platelet function defects

Bleeding defects in Australian patients and families will be characterised using genomic and proteomic analysis more...

Supervisor(s): Ward, Chris (Professor)

ASSESS THE GP GLYCOPROTEIN STRUCTURES OF EBOLA AND MARBURG VIRUS ENVELOPES, THEIR MUCIN-LIKE DOMAINS AND SITES FOR IMMUNE ATTACK

This project extends our published ebola (EBOV) gp's structures, and furthers our studies for immune targeting. Taking a holistic approach our studies aim to examine both the standa more...

Supervisor(s): Lynch, Garry (Dr)

Display of Viral Surface Glycoprotein on Virus like particles (VPLS) for Structure and Immune Epitope Discovery

Unanchored recombinant soluble monomers are often the proteins used in many structure analyses and immunologic testing. But in reality viral surface glycoproteins are orientated, te more...

Supervisor(s): Lynch, Garry (Dr)

Proteomic Mapping and Molecular Modelling of Avian H5N1 Influenza Antigen Epitopes Targeted by Human Antibodies

In studying Avian H5N1 Influenza specific Antibodies within Humans the aim is to clearly and definitively identify the respective viral proteins and epitopes targeted by neutralizin more...

Supervisor(s): Lynch, Garry (Dr)

STUDIES OF VARIABLE OR CONSERVED SURFACE PROTEIN SITES OF NEISSERIA MENINGITIDIS AS EPITOPES FOR STRAIN-SPECIFIC VACCINES OR BROAD-STRAIN (UNIVERSAL) VACCINES

The gram-negative Neisseria Meningititis (NM) remains a significant microbial problem and particularly lethal for the very young. Serogroup B strains are particularly troublesome an more...

Supervisor(s): Lynch, Garry (Dr)