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Red blood cell enucleation

Prior to entering the blood stream, developing erythroid or red blood cells condense and expel their nucleus. This unusual process occurs millions of times per minute in a healthy a more...

Supervisor(s): Fraser, Stuart (Dr)

Link between ATP supply and consumption in the maintenance of the shape of the red blood cell in normal and disease states

The link between the main energy supply (ATP from glycolysis) and its consumption by the cytoskeleton will be studied by using nuclear magnetic resonance (NMR) spectroscopy, compute more...

Supervisor(s): Kuchel, Philip (Emeritus Professor)

Mechanosensation in human erythrocytes: NMR and microscopy studies

We/you will explore the mechanistic basis of the autonomous movement of the plasma membrane of red blood cells, so called membrane flickering. Also, the molecular processes that und more...

Supervisor(s): Kuchel, Philip (Emeritus Professor)

Develop point-of-care microfluidic technologies for cardiovascular and cerebrovascular diseases

We are developing a clinically useful, rapid and high throughput profiling microdevices for thrombosis and coagulation. It will be extremely useful for patients with diabetes, obesi more...

Supervisor(s): Ju, Lining (Arnold) (Dr)

Develop single-cell mechanobiological methods for discovering molecular mechanisms of cardiovascular and neuronal mechanical force sensing

We are developing cutting-edge technologies for the following biomedical application: 1) define the mechanosensing functions of key protein players in the cardiovascular system such more...

Supervisor(s): Ju, Lining (Arnold) (Dr)

Develop single-molecule and super-resolution microscopy imaging technologies in the cardiovascular disease

This project will focus on development, improvement, and application of single-molecule tracking and super-resolution imaging, such as TIRF, HiLo, PALM, STORM, Lattice Light-Sheet M more...

Supervisor(s): Ju, Lining (Arnold) (Dr)

Implantable Medical Devices

The ability to attach functional proteins, antibodies and enzymes to surfaces underpins the development of the next generation of implantable medical devices, biosensors and protein more...

Supervisor(s): Bilek, Marcela (Professor)

STUDIES OF VARIABLE OR CONSERVED SURFACE PROTEIN SITES OF NEISSERIA MENINGITIDIS AS EPITOPES FOR STRAIN-SPECIFIC VACCINES OR BROAD-STRAIN (UNIVERSAL) VACCINES

The gram-negative Neisseria Meningititis (NM) remains a significant microbial problem and particularly lethal for the very young. Serogroup B strains are particularly troublesome an more...

Supervisor(s): Lynch, Garry (Dr)