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Biochemistry and cell biology of the cancer-associated enzyme telomerase

Telomerase is the enzyme responsible for lengthening the ends of chromosomes (telomeres), thereby allowing most cancer cells to divide indefinitely.  We are determining the mec more...

Supervisor(s): Bryan, Tracy (Associate Professor), Cohen, Scott (Dr)

Investigating the role of a novel RNA binding protein in telomerase activity

We have identified a role for a novel RNA binding protein in telomerase biogenesis and recruitment to telomeres. We aim to investigate how this protein functions in this context usi more...

Supervisor(s): Pickett, Hilda (Associate Professor)

Telomere deprotection and cancer

Genome stability in human cells is maintained through the coordinated functions of the DNA damage response. We study these processes with particular interest in the pathways that re more...

Supervisor(s): Cesare, Tony (Dr)

The DNA replication stress response

Genome integrity in human cells is maintained through the coordinated functions of the DNA damage response. We study these processes with particular interest in the pathways that re more...

Supervisor(s): Cesare, Tony (Dr)