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Solute Carrier Transporters

PhD project is available in this laboratory on investigating the relationship of human drug transporters with drugs in treating prevalent diseases such as diabetes and cancers. more...

Supervisor(s): Zhou, Fanfan (Dr)

Molecular dynamics simulations of ion channels and transporters

Understanding the function of ion channels and transporters using molecular dynamics simulations more...

Supervisor(s): Kuyucak, Serdar (Associate Professor)

Bioactive Lipid Modulation of Glycine Transporters and Glycine Receptors

A major focus of our work is on the design, synthesis and development of new bioactive lipids that inhibit glycine transporters. These compounds represent a new class of allosteric more...

Supervisor(s): Vandenberg, Robert (Professor)

Molecular Dynamics of Glutamate Transporters

The aim of this project is to develop a molecular model for the mechanism of glutamate transport and through this we expect to identify novel means of pharmacologically manipulating more...

Supervisor(s): Ryan, Renae (Associate Professor)

A New Therapeutic Strategy to Overcome Multidrug Resistance by Exploiting Drug-Transporters to Target Untreatable Cancers

We recently have discovered a frontier strategy for overcoming drug resistance mediated by P-glycoprotein (Pgp) in the lysosome. Identifying new targets for resistant cancers are cr more...

Supervisor(s): Jansson, Patric (Dr)

The role of autoantibodies against neuronal receptors in immune-mediated neurological and psychiatric disorders.

The neuroimmunology group investigates the role of autoimmunity and inflammation of the brain resulting in neurological disturbance in children. Over the last 5-10 years there has b more...

Supervisor(s): Dale, Russell (Professor), Brilot-Turville, Fabienne (Dr)

Design and synthesis of selective anion receptors to facilitate transmembrane anion transport in epithelial cells

CF is a recessive genetic condition that results from the dysregulation of anion transport through the cystic fibrosis transmembrane regulator anion channel in epithelial cell membr more...

Supervisor(s): Gale, Philip (Professor)

Informatics and Bioinformatics-based Approaches to Protein-Ligand Interaction

The principles of soluble protein structure and ligand docking are applied to structure analysis of membrane bound protein receptors and receptor ligand complexes. more...

Supervisor(s): Church, W Bret (Dr)