About Associate Professor Guy Lyons

Guy's goal is to apply innovative technologies and theories from cellular, molecular and evolutionary biology to understanding the big issues of cancer biology: what drives its progression from normal cell to malignancy, and how it spreads through the body.

We are interested in cancers that affect the tissues that are most exposed to the environment: the skin, the cornea and the oral cavity. These include some of the most commonly occurring cancers. The skin and the cornea are exposed to UV radiation from sunlight, which can cause short term effects on the cells and also mutations, which can cause permanently abnormal behaviour. To study these cells, we genetically manipulate the structure and expression of cancer related genes in them and monitor their effects on cell proliferation, motility and structure. We do this using advanced microscopy methods that enable us to follow them while they are still alive. We use whole genome sequencing technology to identify mutant genes in cancer specimens that drive particular changes in cell behaviour. We also use computer simulations of cancers to understand how changing the behaviour of individual cells through mutating their genes can translate to the pathology of the malignant tissue as a whole, including the roles of various types of cell interactions and evolutionary pathways in this process.

Guy Lyons has a long-standing interest in the molecular and cellular biology of cancer.Guy Lyons completed a PhD at the University of Sydney, postdoctoral fellowships at the University of Alabama at Birmingham, USA, and Institut de Chimie Biologique in Strasbourg, France, and a Senior Research Fellowship at NIH. His lab is currently located in the Centenary Institute and he maintains positions in Dermatology, the Bosch Institute and the Charles Perkins Centre at the University of Sydney, and Cancer Services at Royal Prince Alfred Hospital. He has won competitive grants from international agencies, including the US Army Breast Cancer Research Program, the Human Frontiers Science Program and Worldwide Cancer Research, as well as local funding agencies such as the NHMRC, Cancer Council NSW and Cancer Institute NSW.

Selected publications

For a comprehensive list of Associate Professor Lyons' publicatons, please visit his Sydney Medical School profile page.