About Dr Nial Wheate

Better drugs and better delivery of drugs for the treatment of cancer

Expertise in platinum-based anticancer drugs and the use of drug delivery vehicles such as dendrimers, nanoparticles and macrocycles

Selected publications

  • Gordon J. Kirkpatrick, Jane A. Plumb, Oliver B. Sutcliffe, David J. Flint and Nial J. Wheate, Evaluation of anionic half generation poly(amidoamine) dendrimers as delivery vehicles for the active component of the anticancer drug cisplatin, Journal of Inorganic Biochemistry, 2011, 105, 1115-1122. 
  • Hassan Y. Alniss, Nahoum G. Anthony, Abedawn I. Khalaf, Simon P. Mackay, Colin J. Suckling, Roger D. Waigh, Nial J. Wheate, John A. Parkinson, Rationalising sequence selection by ligand assemblies in the DNA minor groove; The case for thiazotropsin A, Chemical Science, DOI: 10.1039/C2SC00630H.
  • Shonagh Walker, Rajdip Kaur, Fiona J. McInnes and Nial J. Wheate, Synthesis, processing and solid state excipient interactions of cucurbit[6]uril and its formulation into tablets for oral drug delivery, Molecular Pharmaceutics, 2010, 7, 2166-2172. 
  • • Shonagh Walker, Rabbab Oun, Fiona J. McInnes and Nial J. Wheate, The potential of cucurbit[n]urils in drug delivery, Israel Journal of Chemistry, 2011, 51, 616-624. 
  • • Nial J. Wheate, Shonagh Walker, Gemma E. Craig and Rabbab Oun, The status of platinum anticancer drugs in the clinic and in clinical trials, Dalton Transactions, 2010, 39, 8113-8127.  
  • Sarah D. Brown, Paola Nativo, Jo-Ann Smith, David Stirling, Paul R. Edwards, Balaji Venugopal, David J. Flint, Jane A. Plumb, Duncan Graham and Nial J. Wheate, Gold nanoparticles for the improved anticancer drug delivery of the active component of oxaliplatin, Journal of the American Chemical Society, 2010, 132, 4678-4684. 
  • Fiona J. McInnes, Nahoum G. Anthony, Alan R. Kennedy and Nial J. Wheate, Solid state stabilisation of the orally delivered drugs atenolol, glibenclamide, memantine and paracetamol through their complexation with cucurbit[7]uril, Organic and Biomolecular Chemistry, 2010, 8, 765 - 773. 
  • Nial J. Wheate, Virendra Vora, Nahoum G. Anthony and Fiona J. McInnes, Host-guest complexes of the antituberculosis drugs pyrazinamide and isoniazid with cucurbit[7]uril, Journal of Inclusion Phenomena and Macrocyclic Chemistry , 2010, 68, 359-367.
  • Anwen M. Krause-Heuer, Renate Grünert, Sybill Kühne, Magdalena Maruszak, Nial J. Wheate, Delphine Le Pevelen, Leanne R. Boag, Dianne M. Fisher, Jana Kasparkova, Jaroslav Malina, Patrick J. Bednarski, Viktor Brabec and Janice R. Aldrich-Wright, Studies into the mechanism of action of platinum(II) complexes with potent cytotoxicity in human cancer cells, Journal of Medicinal Chemistry, 2009, 52, 5474-5484.
  • Alan R. Kennedy, Alastair J. Florence, Fiona J. McInnes and Nial J. Wheate, A chemical preformulation study of a host-guest complex of cucurbit[7]uril and a multinuclear platinum agent for enhanced anticancer drug delivery, Dalton Transactions, 2009, 7695-7700.