About Professor Steven Meikle

The driver for Steve’s research is the desire to understand human disease processes by extending the capabilities of medical imaging technology.

Professor Steven Meikle is an internationally recognized research leader in the physics of molecular imaging and its applications in pre-clinical research and clinical diagnostics.

Steven Meikle is Professor of Medical Imaging Physics in the Faculty of Health Sciences at the University of Sydney and Director of the University of Sydney/ANSTO Node of the National Imaging Facility at the Brain and Mind Centre. He received his Bachelor of Applied Physics degree (Hons 1 and the University Medal) from the University of Technology, Sydney in 1988 and his Ph.D. degree from the Graduate School of Biomedical Engineering, University of New South Wales in 1995. He was a medical physicist at Royal Prince Alfred Hospital in Sydney (1987-2004), a visiting research associate at the Division of Nuclear Medicine and Biophysics, UCLA School of Medicine in Los Angeles (1991-2) and a post doctoral research scientist at the MRC Cyclotron Unit, Hammersmith Hospital in London (1995-6) before joining the University of Sydney in 2004. 

Professor Meikle’s research interests are the development of instrumentation and computational methods for quantitative molecular imaging techniques such as single photon emission computed tomography (SPECT) and positron emission tomography (PET), and their applications in neuroscience, cancer and metabolic diseases. He made fundamental contributions to the development of quantitative whole body PET, now widely used in staging and evaluation of treatment response for cancer patients, developed one of the first multi-pinhole SPECT animal imaging systems and made important contributions to the development of awake animal imaging with PET and SPECT.

He has published 8 book chapters and more than 180 research articles articles attracting over 4,000 citations. He has current grant support for his research of $2.8 million from national competitive grants. Professor Meikle was awarded the Boyce Worthley Prize for distinction in the practice of physical and engineering sciences in medicine from the ACPSEM in 1994, is a Fellow of the Australian Institute of Physics and a Senior Member of the Institute for Electrical and Electronics Engineers (IEEE) and serves on the Editorial Board of the journal Physics in Medicine and Biology.

For further information, please see Prof Meikle's staff profile:

Selected publications

  1. Meikle SR, Dahlbom M, and Cherry SR, Attenuation correction using count-limited transmission data in positron emission tomography, J Nucl Med, 34: 143-150, 1993. [PMID: 8418258]
  2. Tan P, Bailey DL, Meikle SR, Eberl S, Fulton RR, and Hutton BF, A scanning line source for simultaneous emission and transmission measurements in SPECT, J Nucl Med, 34: 1752-1760, 1993. [PMID: 8410294]
  3. Meikle SR, Hutton BF, and Bailey DL, A transmission dependent method for scatter correction in SPECT, J Nucl Med, 35: 360-367, 1994. [PMID: 8295011]
  4. Meikle SR, Hutton BF, Bailey DL, Hooper PK, and Fulham MJ, Accelerated EM reconstruction in total body PET: potential for improving tumour detectability, Phys Med Biol, 39: 1689-1704, 1994. [PMID: 15551539]
  5. Meikle SR, Bailey DL, Hooper PK, Eberl S, Hutton BF, Jones WF, Fulton RR, and Fulham MJ, Simultaneous emission and transmission measurements for attenuation correction in whole body PET J Nucl Med, 36: 1680-1688, 1995. [PMID: 7658231]
  6. Fulton RR, Meikle SR, Eberl S, Pfeiffer J, Constable CJ. Correction for head movements in positron emission tomography using an optical motion-tracking system. IEEE Trans Nucl Sci. 49 (1): 116-123, 2002.
  7. Kyme AZ, Zhou VW, Meikle SR, Fulton RR. Real-time 3D motion tracking for small animal brain PET. Phys Med Biol, 53:2651-2666, 2008. [PMID: 18443388]
  8. Kyme AZ, Zhou VW, Meikle SR, Baldock C, Fulton RR. Optimised motion tracking for positron emission tomography studies of brain function in awake rats. PLoS ONE 6(7): doi:10.1371/journal.pone.0021727, 2011. [PMID: 21747951]
  9. Meikle SR, Kench P, Kassiou M, Banati RB. Small animal SPECT and its place in the matrix of molecular imaging technologies. Phys Med Biol. 50:R45-R61, 2005. [PMID: 16264248]
  10. Lehnert W, Gregoire M-C, Reilhac A, Meikle SR. Characterization of partial volume effect and region-based correction in small animal positron emission tomography (PET) of the rat brain. NeuroImage 60(4):2144-2157, 2012. [PMID: 22387126]