About Associate Professor Bing Yu

To understand complex genetic diseases.

Associate Professor Bing Yu is an experienced researcher in Molecular Genetics and is interested in the identification of functional DNA variants involving gene-environment interaction and contributing to complex disease.

Associate Professor Bing Yu has a strong research background in molecular genetics. In early positional cloning, he independently found the changes in the cardiac myosin binding protein C gene responsible for familial hypertrophic cardiomyopahty. He has since identified the mutations in this and other genes in > 50 families. His current research continues on the theme of gene discovery and focuses on the genes for the complex traits involving the gene-environment interactions. He was one of the first to show the ACE gene is associated with athlete performance (Human Genetics 1998; 103:48-50), which has over 100 citations. This has recently been followed with another paper identifying a key gene in terms of regulating the anaerobic to aerobic transition (Human Genetics 2005;118:416-423). He also identified the impact of nutrients (eg. sialic acid) on gene expression and learning, and found several associations of the motor neuron disease (MND) with viral infection and environmental toxins along with nutrition and MND teams, respectively. Associate Professor Yu has established DHPLC service in the University’s central DNA analysis facility, SUPAMAC. He was an invited contributor for “DHPLC and mutation detection” in the reference book “Current Protocols in Human Genetics”. In 2006 he spent 8 months in the RNA Laboratory, Center for Genetic Medicine in Northwestern University learning the functional assay of pre-mRNA splicing. He successfully mastered the techniques in RNA-related analysis and now sets up his laboratory looking for the non-protein coding variants from the view of RNA processing. As well as “wet laboratory based skills”, Associate Professor Yu has a strong interest in in silico search for the genes of complex traits. He actively participated in Australasian Human Gene Mapping Meetings and is an invited author for “In silico gene discovery” in a book “Clinical Bioinformatics”.

Selected publications

For a comprehensive list of Associate Professor Yu's publicatons, please visit his Sydney Medical School profile page.