About Associate Professor Anandwardhan Hardikar

I had been engaged in understanding the developmental and regenerative biology of the pancreas since the inception of my research career as a graduate student at the National Centre for Cell Science, India. Here, the Institute’s founder Director Professor Ulhas Wagh influenced my thinking to apply scientific information to real life. Today, I attempt to use my research skills to discover potential tools for early detection and/or treatment of diabetes.

Research in the laboratory is focused on understanding islet biology and development of insulin-producing cells. We work with cadaveric human pancreatic islets as well as biliary duct and gallbladder-derived cells to gather information that would help us understand development of insulin-producing cells. Our previous studies using next generation sequencing of developing human pancreas using the SOLiD platform have provided insight to understanding the role of ncRNAs (specifically microRNAs) in development and differentiation of insulin-producing cells. Present research projects involve applying this information to differentiation of human pancreatic progenitor cells. In addition to these studies, other projects in the lab are focused on understanding the epigenetic modifications in insulin-producing cells in a unique model of multigeneration undernutrition. These studies involve understanding the influence of diet, micronutrients, intrautetine programming and gut microbiota in development of central adiposity, insulin resistance and type 2 diabetes.

I received MSc in Zoology (Genetics) and a PhD on pancreas regeneration and diabetes from the University of Pune. After successful completion of my PhD work, carried out mainly at the National Centre for Cell Science and partly at the WHO centre, Catholic University of Louvain, Louvain-La-Neuve, Belgium, I continued training in the field of pancreas biology and diabetes at the University of Pennsylvania, School of Medicine, where I worked with Doris Stoffers. I then went on to Sydney, Australia to work with Professor Bernie Tuch at the University of New South Wales where I pursued my research interests in transplantation of insulin-producing surrogate b-cells. After my research tenure in the laboratory of Marvin Gershengorn, Scientific Director, NIDDK, NIH, Bethesda, MD, I went on to join the National Centre for Cell Science, Pune, India. I work with the Diabetes and Stem Cell Research at the O'Brien Institute and ACU Centre, Melbourne, Australia. I presently lead the Diabetes and Islet-biology Group at the NHMRC Clinical Trials Centre, University of Sydney, Australia.

Present members in the lab are:
1) Dr. Mugdha Joglekar (JDRF Post-doctoral Research Fellow, Sydney)
2) Dr. Sarang Satoor (Post-doctoral Research Fellow, Sydney)
3) Mr. Wilson Wong (Research Assistant, Sydney)
4) Mr. Michael Williams (PhD Student, University of Melbourne)
5) Mrs Malati Umrani (PhD Student, NCCS, India)
6) Ms Subhshri Sahu (PhD Student, NCCS, India)

Selected publications

For a comprehensive list of Associate Professor Hardikar's publications, please visit his Sydney Medical School academic profile.