About Associate Professor Simon Lewis

Associate Professor Lewis is a nationally and internationally recognised researcher in Parkinson’s Disease (PD), dementia, neuroimaging and sleep-wake disorders. In 2009, he established a PD research clinic at the BMRI, which has already performed detailed longitudinal assessments in over 500 volunteers.

This program of research will examine the impact of a multifaceted psychoeducation program targeting the sleep-wake disturbances that commonly affect patients with Parkinson’s disease (PD). Previous work within the Ageing Brain Program at the Brain & Mind Research Institute has developed the “Sleep Well; Think Well” program, an 8-week group based learning course for older individuals with sleep complaints. The proposed study would determine whether this program is effective in patients with PD who are known to suffer with high rates of sleep-wake disturbance. The project would also offer opportunities for the candidate to develop expertise in understanding objective biomarkers of sleep including actigraphy, polysomnography and functional neuroimaging.

Associate Professor Lewis is a nationally and internationally recognised researcher in Parkinson's Disease (PD), dementia, neuroimaging and sleep-wake disorders. Over his very brief research career investigating Parkinson's disease he has already reported the first work that objectively characterised phenotypic sub-groups of patients. In addition he published the first study to utilise functional magnetic resonance imaging to identify the neural correlates of executive dysfunction in PD, as well as two separate novel hypotheses explaining the phenomena of freezing of gait and visual hallucinations. In 2009, he established a PD research clinic at the BMRI, which has already performed detailed longitudinal assessments in over 500 volunteers. This clinic seeks to recruit patients into a range of research projects directed towards improving quality of life for people living with neurodegenerative diseases. This work combines both his clinical experience with basic neuroscience and current projects currently utilise a varied number of approaches including functional and structural magnetic resonance imaging, chronobiology and sleep laboratory studies, neuropsychology, neuropsychiatry, neurophysiology and electroencephalography. Recognising the enormous potential significance of having brain donors who have been well characterised during life, the Sydney Brain Bank recently invited Associate Professor Lewis to head the NSW Movement Disorders Brain Donor Program allowing ultimately for detailed cliniconeuropathological correlations to be made. His research has attracted significant media attention and he has been featured on national radio and national television news, as well as the ABC's Catalyst program.

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Selected publications

Selected publications For a comprehensive list of Associate Professor Lewis's publications, please visit his Sydney Medical School academic profile.