About Associate Professor Mark Gorrell

Associate Professor Mark Gorrell is expert in the prolyl oligopeptidase enzyme family, in particular the biochemistry, biology and molecular and cellular biology of dipeptidyl peptidase (DPP) IV.

Understanding the functions of the five enzymes of the prolyl oligopeptidase family and the molecular pathogenesis of chronic liver disease in mouse and human.

Associate Professor Gorrell has extensive experience in liver disease pathogenesis using multiple approaches including histology, immunohistochemistry, biochemistry, mouse models and genomics. His other primary interest is the prolyl oligopeptidase gene family, especially dipeptidyl peptidase (DPP) IV, and studies of liver pathology in gene knockout mouse strains subjected to models of chronic liver injury. These studies are focussed on preventing cirrhosis and liver cancer by developing greater understanding of the molecular mechanisms of disease progression.

Following postdoctoral training in immunology at the University of Melbourne and four years of higher training in cell biology, protein biochemistry and virus pathogenesis at Johns Hopkins University in the USA, Associate Professor Gorrell returned to Sydney in 1994. He then initiated structure-function studies of DPPIV that proved both correct and crucial when the 3D structure was solved after DPPIV became a therapeutic target in diabetes. Associate Professor Gorrell expanded this work to functional and biochemical studies of all enzymes of the DPPIV gene family, DPPIV, fibroblast activation protein (FAP), DPP8 and DPP9. His goal is to improve human health by understanding the distinct functions of each of the four enzymes of the DPPIV family. He has patents on DPP8 and DPP9 for measuring the DPPIV versus DPP8 and DPP9 selectivity of inhibitory compounds. He discovered that FAP is important in liver disease. He regularly reviews the DPPIV field and is invited to speak at international DPPIV conferences. He is an author of 106 publications, including invited book chapters and reviews. Hirsch index 24.

He has completed supervising 10 postgraduate students and 10 Honours students.

Centenary Institute of Cancer Medicine and Cell Biology, Molecular Hepatology Group

Selected publications

For a comprehensive list of Associate Professor Gorrell's publicatons, please visit his Sydney Medical School profile page.