About Dr Ann Kwan

Ann has international recognition in the use of spectroscopic techniques, especially Nuclear Magnetic Resonance (NMR) spectroscopy to solve interesting biological problems. She also has extensive experience with molecular biology, protein engineering, protein chemistry and biophysics.

Over the last ten years, Ann has focused on understanding how hydrophobin proteins self-polymerise into an amphipathic amyloid film at interfaces and on determining the molecular structure of these films. Hydrophobins are small proteins which serve a number of important roles in fungal biology, the most notable being the formation of a protective, water-proof layer on aerial surface structures. Ann pioneered a system for the recombinant expression and in vitro oxidative refolding of hydrophobins which enabled straight forward engineering and labeling of this family of proteins for mutagenesis and NMR studies. These studies have revealed the structural features and the molecular mechanism of how hydrophobins function and assemble and offered new opportunities to develop next generation anti-microbial/fungal agents and biomaterials. In addition, Ann has carried out or directed the structure determination/structural studies of many proteins and protein domains, as well as characterisation of protein:protein interactions and dynamics. These include zinc fingers in isolation and in complex with nucleic acids or other proteins/peptides, an antifreeze protein, the N-terminal domain from a histidine kinase inhibitor and a protein implicated in Familial Hypertrophic Cardiomyopathy.

Dr Ann Kwan is a researcher in the School of Life and Environmental Sciences  

Dr Kwan is also a member of The University of Sydney Nano Institute

For more information on Dr Kwan, refer to her Academic Profile Online