About Dr Ashley Waardenberg

Dr Waardenberg's research interests include the application and development of bioinformatics/systems biology methods, including machine learning and network theory, for understanding developmental biology and disease processes.

Most of Dr Waardenberg's focus has been around understanding how disease develops and the identification of markers and validation of biological process related to human diseases. Dr Waardenberg has a number of projects on offer to keen students who are interested in gene regulatory networks, systems biology, machine learning, network theory, developmental biology, and how these approached can be used and/or developed further for understanding human disease.

Dr Waardenberg received a PhD in Systems Biology under the supervision of Prof Christine Wells and Dr Brian Dalrymple where he developed a novel visualisation approach for integrating gene expression and protein spatial location. A key outcome of this approach included the discovery of an interaction between PI3K and the muscle contractile apparatus, in particular a role with Melusin (a muscle mechano-sensor) (Waardenberg, et al. JBC, 2011).

Dr Waardenberg was also involved in the Bovine Genome Consortia, published in Science (2009) and was a team recipient of the CSIRO Chairman’s Medal in 2010 for contributions to this international effort.

Dr Waardenberg was previously a postdoctoral bioinformatician in the Cardiac Development and Stem Cell Biology Laboratory of Professor Richard Harvey at the Victor Chang Cardiac Research Institute, where he implemented systems biology strategies for understanding genome-wide binding effects of the cardiac transcription factor NKX2-5 and mutations relevant to congenital heart disease and continues to collaborate (Waardenberg AJ, Ramialison M et al CSHL Persp. Medicine, 2014; Bouveret R, Waardenberg AJ et al. eLIFE, 2015; Waardenberg AJ et al. BMC Bioinformatics, 2015).

Dr Waardenberg is currently a postdoctoral bioinformatican at the Children’s Medical Research Institute where he is developing systems biology approaches for investigating high throughput protein modification data [phosphoproteomics data (Koslov SV, Waardenberg AJ et al. MCP 2016)] related to neuronal signalling and multi-omics integrative analyses.

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Selected publications

For a comprehensive list of Dr Waardenberg's publications please see his Sydney Medical School profile page.