About Dr Yorgi Mavros

My research primarily focusses on the use of exercise in the prevention and management of chronic disease. I have a specific interest in using progressive resistance training, or weight training, and how changes in muscle mass and muscle strength following this mode of exercise are associated with health outcomes. Sarcopenia is a term used to describe the progressive loss of muscle mass, strength and function, as we age. Sarcopenia has recently received an International Classification of Disease (ICD) code, identifying it as a condition requiring treatment. Currently, no effective pharmacological or dietary treatment exists that addressed the loss of muscle mass, strength and function. Thus, progressive resistance training, which is anabolic in nature and address all the components of sarcopenia, remains the most potent and effective strategy.

I received my PhD in 2013 in a trial of progressive resistance training in type 2 diabetes. Since then, my experience has expanded to include other chronic diseases typically affecting older adults with sarcopenia and obesity. These include cognitive impairment and dementia, osteoarthritis and cardiovascular and peripheral vascular disease. While my focus is on the use of progressive resistance training in chronic diseases typically associated with sarcopenia and obesity, I am currently co-supervising students investigating the use of ergogenic effects of listening to music during exercise, as well as the role of genetics on fuel utilisation during exercise.

I recently published data which showed for the first time, a direct link between improvements in muscle strength, and improvements in cognitive function following 6 months of progressive resistance training in adults with cognitive impairment. I was fortunate enough for this to generate a lot of media attention, with dementia being the 2nd leading cause of death in Australia. No current therapy exists that can effectively prevent dementia, and so more work is needed on the role of exercise in the prevention of cognitive decline and dementia, as this is currently our most effective strategy.

Selected publications

  1. Mavros, Y., N. Gates, G.C. Wilson, N. Jain, J. Meiklejohn, H. Brodaty, W. Wen, N. Singh, B.T. Baune, and C. Suo, Mediation of Cognitive Function Improvements by Strength Gains After Resistance Training in Older Adults with Mild Cognitive Impairment: Outcomes of the Study of Mental and Resistance Training. Journal of the American Geriatrics Society, 2016.
  2. Mavros, Y., E. O'Neill, M. Connerty, J.F. Bean, K. Broe, D.P. Kiel, D. MacLean, A. Taylor, R.A. Fielding, and M. Fiatarone Singh, Oxandrolone augmentation of resistance training in older women: a randomized trial. Med Sci Sports Exerc, 2015. 47(11): p. 2257-67.
  3. Mavros, Y., S. Kay, K.A. Simpson, M.K. Baker, Y. Wang, R.R. Zhao, J. Meiklejohn, M. Climstein, A.J. O'Sullivan, and N. de Vos, Reductions in C‐reactive protein in older adults with type 2 diabetes are related to improvements in body composition following a randomized controlled trial of resistance training. Journal of cachexia, sarcopenia and muscle, 2014. 5(2): p. 111-120.
  4. Mavros, Y., S. Kay, K.A. Anderberg, M.K. Baker, Y. Wang, R. Zhao, J. Meiklejohn, M. Climstein, A. O'Sullivan, and N. de Vos, Changes in insulin resistance and HbA1c are related to exercise-mediated changes in body composition in older adults with Type 2 diabetes interim outcomes from the GREAT2DO trial. Diabetes Care, 2013. 36(8): p. 2372-2379.
  5. Suo, C., M. Fiatarone Singh, N. Gates, W. Wen, P. Sachdev, H. Brodaty, N. Saigal, G. Wilson, J. Meiklejohn, and N. Singh, Therapeutically relevant structural and functional mechanisms triggered by physical and cognitive exercise. Molecular Psychiatry, 2016: p. doi: 10.1038/mp.2016.19.
  6. Jayewardene, A.F., Y. Mavros, D.P. Hancock, T. Gwinn, and K.B. Rooney, Associations between CD36 gene polymorphisms, fat tolerance and oral fat preference in a young-adult population. European Journal of Clinical Nutrition, 2016: p. Doi: 10.1038/ejcn.2016.132.
  7. Jayewardene, A., Y. Mavros, A. Reeves, D. Hancock, T. Gwinn, and K. Rooney, Interactions Between Fatty Acid Transport Proteins, Genes that Encode for Them, and Exercise: A Systematic Review. Journal Of Cellular Physiology, 2015: p. DOI: 10.1002/jcp.25281.
  8. Jayewardene, A., Y. Mavros, T. Gwinn, D. Hancock, and K. Rooney, Associations between CD36 gene polymorphisms and metabolic response to a short-term endurance training program in a young-adult population. Applied Physiology, Nutrition, and Metabolism, 2015. 41(2): p. 157-167.
  9. Simpson, K., Y. Mavros, S. Kay, J. Meiklejohn, N. de Vos, Y. Wang, Q. Guo, R. Zhao, M. Climstein, and B. Baune, Graded Resistance Exercise And Type 2 Diabetes in Older adults (The GREAT2DO study): methods and baseline cohort characteristics of a randomized controlled trial. Trials, 2015. 16(512): p. 14.
  10. Guerrero, Y., N. Soomro, G. Wilson, Y. Dam, J. Meiklejohn, K. Simpson, R. Smith, J. Brand-Miller, M. Simic, and H. O'Connor, Train High Eat Low for Osteoarthritis study (THE LO study): protocol for a randomized controlled trial. Journal of Physiotherapy, 2015.