About Professor Chris O'Neill

My research focuses on the molecular and cellular control of early embryo development. It pays particular attention to how fertilisation and early embryo development in sub-optimal environments impact the health of individuals throughout the rest of their life.

The lab investigates the processes of the epigenetic control of normal patterns of gene expression during key embryonic transitions, particularly the first rounds of cellular differentiation. We are interested in how modern forms of assisted reproductive technology, and parental disease states (including diabetes and obesity) influence these processes, and how this impacts subsequent normal development. As well as investigation of these processes in embryos, we also use embryonic stem cell populations as models for investigation of normal development. Our studies will lead to an improved understanding and development of strategies to reduce the health burden across the population caused by abnormal development.

Selected publications

For a full list of publications see Professor Chris O'Neill's Academic Profile page