About Professor John Grigg

My research is focused on inherited eye disease. This involves investigating the genetic aetiology, understanding the natural history of inherited retinal disorders, development of novel therapies using animal and stem cell models. Health economics in inherited eye diseases. My goal is to find therapies for currently untreatable blinding conditions.

I am a Clinician Scientist with clinical expertise in Paediatric ophthalmology, glaucoma visual electrophysiology and genetic eye diseases. My research exams genotype -phenotype correlations in inherited eye diseases. Assessment of animal models of inherited eye disease. Implementation of clinical trials for novel therapies for blinding eye disease

Professor Grigg is an internationally recognised clinician scientist in Paediatric Ophthalmology and Genetic Eye disease. He is Head, Discipline of Ophthalmology, University of Sydney. He has qualifications in ophthalmology (MBBS, MD, FRANZCO FRACS) and research and clinical training in paediatric ophthalmology, inherited eye disease, visual electrophysiology and glaucoma. Professor Grigg heads the Electrophysiology Units at Save Sight Institute, Sydney Eye Hospital Campus, the largest in Australia, and at the Children's Hospital at Westmead (CHW). His leadership has developed the visual electrophysiology and imaging services into international recognised centres, enabling accurate phenotyping of inherited retinal disease patients and facilitating interpretation of genomic data, genetic diagnosis and disease monitoring. He conducts inherited eye disease clinics at both the Sydney Eye Hospital and CHW, Sydney.
Research relevant to the proposed project
Prof Grigg has significant expertise in visual electrophysiology and ocular multimodal imaging which is critical to this research proposal. Prof Grigg oversees mouse electrophysiology and ocular imaging to the Eye Genetics Research Unit at the Children's Medical Research Institute. This has enabled detailed phenotyping of mouse models of inherited retinal diseases, that is used to monitor ocular phenotypic features in the mouse model under investigation.

Prof Grigg is currently a CI on two NHMRC project grants including, APP1099165, "Pathways to treatment in binding genetic retinal disease", and APP1109056, "Clinical trial of a suprachoroidal visual prosthesis for the profoundly vision impaired" and is CIF on a current NHMRC Centre for Research Excellence grant, APP1116360. He has also received regular funding from the Ophthalmic Research Institute of Australia and Retina Australia. For a comprehensive profile of Dr. John Grigg, please visit Sydney Medical School profile page.

Selected publications

1. Nash BM, Symes R, Goel H, Dinger ME, Bennetts B, Grigg JR, Jamieson RV. NMNAT1 variants cause cone and cone-rod dystrophy. European Journal of Human Genetics. 2018;26(3):428-33.
2. Ma AS, Grigg JR, Prokudin I , Flaherty M, Bennetts B, Jamieson RV. New mutations in GJA8 expand the phenotype to include total sclerocornea. Clinical Genetics. 2018;93(1):155-9.
3. MacGregor S, Ong JS, An J, Han X, Zhou T, Siggs OM, et al. Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma. Nature Genetics. 2018;50(8):1067-71.
4. Gharahkhani P, Burdon KP, Cooke Bailey JN, Hewitt AW, Law MH, Pasquale LR, et al. Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma. Scientific Reports. 2018;8(1):3124.
5. Jayanetti V, Klistorner AI, Graham SL, Dexter M, Flaherty MP, Jones K, et al. Monitoring of optic nerve function in Neurofibromatosis 2 children with optic nerve sheath meningiomas using multifocal visual evoked potentials. Journal of Clinical Neuroscience. 2018;02:02.
6. Gharahkhani P, Burdon KP, Cooke Bailey JN, Hewitt AW, Law MH, Pasquale LR, et al. Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma. Scientific Reports. 2018;8(1):3124.
7. Ma AS, Grigg JR, Ho G, Prokudin I, Farnsworth E, Holman K, Cheng, ·A. Billson, FA. Martin, FJ. Fraser, C. Mowat, ·D. Smith, J. Christodoulou, J. Flaherty, ·M. Bennetts, ·B. Jamieson, ·RV. Sporadic and Familial Congenital Cataracts: Mutational Spectrum and new Diagnoses using Next-Generation Sequencing. Hum Mutat. 2016;37(4):371-84.
8. Greenlees R, Mihelec M, Yousoof S, Speidel D, Wu S, Rinkwitz S, Prokudin, I. Perveen, R. Cheng, A. Ma, A. Nash, B. Gillespie, R. Loebel, DA. Clayton-Smith, J. Lloyd, IC. Grigg, JR. Tam, PP. Yap, AS. Becker, TS. Black, GC. Semina, E. Jamieson, RV. Mutations in SIPA1L3 cause eye defects through disruption of cell polarity and cytoskeleton organization. Human Molecular Genetics. 2015;24(20):5789-804.
9. Nash B, Wright D, Grigg J, Bennetts B, Jamieson R. Retinal dystrophies, genomic applications in diagnosis and prospects for therapy. Translational Pediatrics. 2015; 4:139-63.
10. Zagora SL, Funnell CL, Martin FJ, Smith JE, Hing S, Billson FA, et al. Primary Congenital Glaucoma outcomes: Lessons from 23 years of follow-up. Am J Ophthalmol. 2015;159(4):788-96.e2.